Pegloticase Safe & Effective for Patients with Gout on Dialysis

In the analysis of these hemodialysis patients, the investigators concluded that pegloticase treatment for refractory gout was safe and effective. Erythropoiesis-stimulating agent (ESA) use was similar before and after pegloticase treatment, but the investigators noticed a significantly lower monthly dose requirement after pegloticase treatment. The monthly ESA dose (n=38) prior to pegloticase was 55,314 units, after pegloticase the monthly ESA dose (n=37) was 37,290 units. This difference was statistically significant and warrants further investigation.

Michele B. Kaufman, PharmD, BCGP, is a freelance medical writer based in New York City and a pharmacist at New York Presbyterian Lower Manhattan Hospital.

References

U.S. Food & Drug Administration. Center for drug evaluation and research summary review: Application 125293. 2010 Sep 14.
Bleyer AJ, Zhang Y, Kshirsagar, et al. Pegloticase therapy in gout patients undergoing dialysis: a USRDS database study [abstract 183]. 2021 Apr.

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Pegloticase is a new alternative therapy for patients with severe, refractory gout unresponsive to other urate-lowering agents. The goal of this therapy is to reduce disease burden, tophi size and frequency of flares and to improve quality of life when other treatments have failed. Persistent lowering of plasma uric acid (PUA) to less than 6…

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In light of the release of the ACR’s new gout guideline, it’s not surprising that 50 abstracts of studies on various aspects of gout were accepted at ACR Convergence 2020. Here, we highlight just a few:

How to Manage Pain in Patients with Renal Insufficiency or End-Stage Renal Disease on Dialysis

Treatment Options for Severe Refractory Gout When Pegloticase Fails

Study: Pegloticase & Methotrexate Co-Treatment Helps Uncontrolled Gout

Dr. Ethan Craig Picks His Favorite Gout Abstracts from ACR Convergence 2020

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