The Rheumatologist
COVID-19 NewsACR Convergence
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
      • Gout Resource Center
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Resource Centers
    • Axial Spondyloarthritis Resource Center
    • Gout Resource Center
    • Psoriatic Arthritis Resource Center
    • Rheumatoid Arthritis Resource Center
    • Systemic Lupus Erythematosus Resource Center
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
    • Interprofessional Perspective
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
    • Electronic Health Records
    • Apps
    • Information Technology
    • From the College
    • Multimedia
      • Audio
      • Video
  • Resources
    • Issue Archives
    • ACR Convergence
      • Gout Resource Center
      • Axial Spondyloarthritis Resource Center
      • Psoriatic Arthritis
      • Abstracts
      • Meeting Reports
      • ACR Convergence Home
    • American College of Rheumatology
    • ACR ExamRheum
    • Research Reviews
    • ACR Journals
      • Arthritis & Rheumatology
      • Arthritis Care & Research
      • ACR Open Rheumatology
    • Rheumatology Image Library
    • Treatment Guidelines
    • Rheumatology Research Foundation
    • Events
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / Predicting the Future: Prognostication in Rheumatoid Arthritis

Predicting the Future: Prognostication in Rheumatoid Arthritis

July 19, 2022 • By Jason Liebowitz, MD

  • Tweet
  • Email
Print-Friendly Version / Save PDF

Anti-advanced glycated end-products (anti-AGE) antibodies have been seen in patients with diabetes and cardiovascular disease, but some data indicates that, in RA, these antibodies may correlate with disease activity.

You Might Also Like
  • Not Your Average Case: Difficult-to-Treat Rheumatoid Arthritis
  • California Rheumatology Alliance 2013 Meeting: The Future of Rheumatoid Arthritis
  • The Future of Rheumatoid Arthritis Treatment
Explore This Issue
September 2022
Also By This Author
  • The Great Debate: Should Jakinibs Be Used Before Biologics after Methotrexate Failure in RA?

In evaluating nearly 1,200 patients enrolled in the Leiden early arthritis cohort, van der Woude et al. were able to measure anti-MAA and anti-AGE antibodies and perform statistical analyses looking at the prevalence and co-occurrence of antibodies, associations with genetic risk factors and associations with different phenotypes of disease.4

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

These researchers were able to show that anti-MAA and anti-AGE antibodies exist in patients with seropositive and seronegative RA and, at a lower prevalence, in patients with such conditions as psoriatic arthritis and crystalline arthritis. More specifically, these antibodies help identify a subgroup among patients with seronegative RA who are also positive for HLA-DRB1*03:01, have increased markers of inflammation and have shown some degree of radiographic progression. Although these antibodies are not a panacea, they may help sub-classify patients within disease categories.

In Sum

A great deal remains to be learned about disease pathogenesis, identifying patients at risk for progression of disease and knowing when to intervene in preclinical disease.

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

Jason Liebowitz, MD, completed his fellowship in rheumatology at Johns Hopkins University, Baltimore, where he also earned his medical degree. He is currently in practice with Skylands Medical Group, N.J.

References

  1. Emery P, Horton S, Dumitru RB, et al. Pragmatic randomised controlled trial of very early etanercept and MTX versus MTX with delayed etanercept in RA: The VEDERA trial. Ann Rheum Dis. 2020 Apr;79(4):464–471. [Published correction appears in Ann Rheum Dis. 2021 Mar;80(3):e45.]
  2. den Hollander N, Verstappen M, Sidhu N, et al. Hand and foot MRI in contemporary undifferentiated arthritis: In which patients is MRI valuable to detect rheumatoid arthritis early? A large prospective study [OP0083]. Ann Rheum Dis. 2022;81(suppl 1):55–56.
  3. Perniola S, Tolusso B, Elmesmari A, et al. Digital spatial profiling reveals distinct synovial tissue macrophage transcriptomic signature of sustained remission in rheumatoid arthritis patients at risk of disease flare after treatment cessation [OP0084]. Ann Rheum Dis. 2022;81(suppl 1):56.
  4. van Wesemael TJ, van den Beukel MD, Hoogslag ATW, et al. Antibodies against advanced glycation end-products (anti-age) distinguish patients with a more inflammatory profile and worse outcome in seronegative rheumatoid arthritis [OP0086]. Ann Rheum Dis. 2022;81(suppl 1):57.

Pages: 1 2 3 | Single Page

Filed Under: Conditions, Meeting Reports, Rheumatoid Arthritis Tagged With: anti-advanced glycated end-products (anti-AGE) antibodies, anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies, EULAR, EULAR 2022, RA Resource Center, Rheumatoid Arthritis (RA), synovial, TenosynovitisIssue: September 2022

You Might Also Like:
  • Not Your Average Case: Difficult-to-Treat Rheumatoid Arthritis
  • California Rheumatology Alliance 2013 Meeting: The Future of Rheumatoid Arthritis
  • The Future of Rheumatoid Arthritis Treatment
  • Tissue Evaluation: Understanding Rheumatoid Arthritis Inside & Out

Meeting Abstracts

Browse and search abstracts from the ACR Convergence and ACR/ARP Annual Meetings going back to 2012.

Visit the Abstracts site »

Simple Tasks

Learn more about the ACR’s public awareness campaign and how you can get involved. Help increase visibility of rheumatic diseases and decrease the number of people left untreated.

Visit the Simple Tasks site »

American College of Rheumatology

Visit the official website for the American College of Rheumatology.

Visit the ACR »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use / Cookie Preferences

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2023 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)