RA and Lupus
More Clues to Genetic Roots of RA and SLE
Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of RA and systemic lupus erythematosus. N Engl J Med. 2007;357(10):977-986.
Explore this issueDecember 2007
Background: RA is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q.
Methods: We tested single-nucleotide polymorphisms (SNPs) in and around 13 candidate genes within the previously linked chromosome 2q region for association with RA. We then performed fine mapping of the STAT1-STAT4 region in a total of 1,620 case patients with established RA and 2,635 controls, all from North America. Implicated SNPs were further tested in an independent case-control series of 1,529 patients with early RA and 881 controls, all from Sweden, and in a total of 1,039 case patients and 1,248 controls from three series of patients with systemic lupus erythematosus (SLE).