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Researchers Give Update on Janus Kinase (JAK) Inhibitors

Kimberly Retzlaff  |  Issue: May 2020  |  

Kimberly Retzlaff is a freelance medical journalist based in Denver.

References

  1. Curtis JR, Lee EB, Kaplan IV, et al. Tofacitinib, an oral Janus kinase inhibitor: Analysis of malignancies across the rheumatoid arthritis clinical development programme. Ann Rheum Dis. 2016 May;75(5):831–841.
  2. Cohen S, Radominski SC, Gomez-Reino JJ, et al. Analysis of infections and all‐cause mortality in phase II, phase III, and long‐term extension studies of tofacitinib in patients with rheumatoid arthritis. Arthritis Rheumatol. 2014 Nov;66(11):2924–2937.
  3. Winthrop KL, Park S-H, Gul A, et al. Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis. Ann Rheum Dis. 2016 Jun;75(6):1133–1138.
  4. Winthrop KL, Yamanaka H, Valdez H, et al. Herpes zoster and tofacitinib therapy in patients with rheumatoid arthritis. Arthritis Rheumatol. 2014 Oct;66(10):2675–2684.
  5. Lilly. Baricitinib (LY3009104): Rheumatoid Arthritis (briefing document). NDA 207924. FDA Advisory Committee Meeting. 2018 Apr 23.
  6. Brown T. FDA warns of risk for PE, death with higher dose tofacitinib (Xeljanz) for RA. Medscape. 2019 Feb 25.

* Dr. Winthrop has received research funding from Pfizer and BMS; performed consultant work for Amgen, AbbVie, Pfizer, UCB, Genentech, BMS and Lilly; and serves on the data safety monitoring boards for RCTs conducted by UCB, Roche, Astellas, Lilly, Janssen and Galapagos.

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