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Sonelokimab Promising for Patients with PsA

  |  Issue: December 2024  |  

The 60 mg dose of sonelokimab was adequate to reach high levels of response in the general trial population. However, the 120 mg dose of sonelokimab was found to further improve responses in specific patient subgroups. Therefore, it’s anticipated both doses will be investigated in phase 3 clinical trials.

The discontinuation rates were low (~5%), and the safety profile of sonelokimab was consistent with previous studies. No new safety signals were identified.

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Michele B. Kaufman, PharmD, BCGP, is a freelance medical writer based in New York City and a pharmacist at New York Presbyterian Lower Manhattan Hospital.

References

  1. MoonLake announces significant improvements with nanobody sonelokimab over 24 weeks in active psoriatic arthritis (PsA) and other important updates at its R&D Day [news release]. MoonLake Immunotherapeutics. 2024 Mar 10.
  2. Evaluation of sonelokimab for the treatment of patients with active psoriatic arthritis [NCT05640245]. ClinicalTrials.gov. 2024 Apr 25.
  3. Jin B-K, Odongo S, Radwanska M, et al. Nanobodies: A review of generation, diagnostics and therapeutics. Int J Mol Sci. 2023:24:5994.
  4. Sanofi’s Cablivi (caplacizumab-yhdp): A new era in acquired thrombotic thrombocytopenic purpura (aTTP) treatment [news release]. Sanofi. 2019 Feb 6.

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