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You are here: Home / Articles / Systemic Sjögrens: More Than a Sicca Disease

Systemic Sjögrens: More Than a Sicca Disease

November 1, 2014 • By Pilar Brito-Zerón, MD, PhD, and Manuel Ramos-Casals, MD, PhD, on behalf of the EULAR-SS Task Force Group

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Therefore, the need for a consensus on a homogeneous diagnostic and therapeutic approach to systemic involvement in pSS is clear. The EULAR-SS Task Force Group is now working on the development of EULAR-SS recommendations for the characterization and treatment of organ-specific extraglandular involvement in pSS on the basis of a systematic review of the current scientific evidence. This systematic review revealed a low level of evidence in studies of systemic SS, especially with respect to the diagnostic approach. The body of evidence relied predominantly on information retrieved from individual cases, and the main sources of bias were the heterogeneous definitions of organ involvement—or even the lack of definition in some studies—and the heterogeneous diagnostic approach used in studies to investigate each organ involvement.

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November 2014

A greater understanding of the pathogenesis of systemic immune-mediated damage, along with active international collaborations to develop standardized guidelines, is critical.

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Pilar Brito-Zerón, MD, PhD, and Manuel Ramos-Casals, MD, PhD, both work for the Laboratory of Autoimmune Diseases Josep Font, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona, Spain.

 

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Members of the EULAR-SS Task Force Steering Group are: Manuel Ramos-Casals, Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona, Spain; Pilar Brito-Zerón, Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona, Spain; Raphaèle Seror, Assistance Publique–Hopitaux de Paris, Hôpital Bicêtre, Department of Rheumatology, INSERM U802, Le Kremlin Bicêtre, France; Université Paris-Sud 11; INSERM U1012, Le Kremlin Bicêtre, France, and Center of Clinical Epidemiology, Hôpital Hôtel Dieu, Paris, France; INSERM U738, Université Paris-René Descartes, Paris, France; Hendrika Bootsma, Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Simon J. Bowman, Rheumatology Department, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK; Thomas Dörner, Rheumatology Department, Charité, University Hospital, Berlin, Germany; Jacques-Eric Gottenberg, Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, EA 4438, Strasbourg, France; Xavier Mariette, Assistance Publique–Hopitaux de Paris, Hôpital Bicêtre, Department of Rheumatology, INSERM U802, Le Kremlin Bicêtre, France; Université Paris-Sud 11; INSERM U1012, Le Kremlin Bicêtre, France; Elke Theander, Department of Rheumatology, Malmö University Hospital, Lund University, Sweden; Stefano Bombardieri, Rheumatology Unit, University of Pisa, Pisa, Italy; Salvatore de Vita, Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital Santa Maria della Misericordia, 133100 Udine, Italy; Thomas Mandl, Department of Rheumatology, Malmö University Hospital, Lund University, Lund, Sweden; Wan-Fai Ng, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; Aike Kruize, Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands; Athanasios Tzioufas, Department of Pathophysiology, School of Medicine, University of Athens, Greece; and Claudio Vitali, “Villamarina” Hospital, Department of Internal Medicine and section of Rheumatology, Piombino, Italy, on behalf of the EULAR Sjögren Syndrome Task Force.

Disclosure

Dr. Brito-Zerón is supported by the Josep Font Research Fellow Award, Hospital Clinic, Barcelona, Spain.

References

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Filed Under: Conditions, Rheumatoid Arthritis, SLE (Lupus), Soft Tissue Pain Tagged With: Brito-Zerón, EULAR-SS Task Force Group, Fibromyalgia, IgG4 related disease, Ramos-Casals, Rheumatoid arthritis, sicca, Sjögren's syndrome, Systemic lupus erythematosusIssue: November 2014

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