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The Many Facets of COVID-19: Experts Address Basic & Clinical Research Concepts in the COVID-19 Era

Jason Liebowitz, MD, FACR  |  November 23, 2021

References

  1. Eggertson L. Lancet retracts 12-year-old article linking autism to MMR vaccines. CMAJ. 2010;182(4):E199–E200.
  2. Roberts L. Why measles deaths are surging—and coronavirus could make it worse. Nature. 2020 Apr;580(7804):446–447.
  3. Yang A, Shin J, Zhou A, et al. The battleground of COVID-19 vaccine misinformation on Facebook: Fact checkers vs. misinformation spreaders. Harvard Kennedy School Misinformation Review. 2021. https://doi.org/10.37016/mr-2020-78.
  4. Sparks JA, Wallace ZS, Seet AM, et al. Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry. Ann Rheum Dis. 2021 Sep;80(9):1137–1146. Epub 2021 May 28.
  5. Bastard P, Rosen LB, Zhang Q, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Oct 23;370(6515):eabd4585. Epub 2020 Sep 24.
  6. Abers MS, Rosen LB, Delmonte OM, et al. Neutralizing type-I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID-19. Immunol Cell Biol. 2021 Oct;99(9):917–921. Epub 2021 Aug 8.
  7. Tipton CM, Fucile CF, Darce J, et al. Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus. Nat Immunol. 2015 Jul;16(7):755–765. Epub 2015 May 25.
  8. Woodruff MC, Romonell RP, Nguyen DC, et al. Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19. Nat Immunol. 2020 Dec;21(12):1506–1516. Epub 2020 Oct 7.
  9. Woodruff MC, Romonell RP, Saini AS, et al. Relaxed peripheral tolerance drives broad de novo autoreactivity in severe COVID-19. medRxiv. 2021 Jul 27;2020.10.21.20216192. Preprint.
  10. Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19). U.S. Centers for Disease Control and Prevention. 2020 Mar 27.
  11. McArdle AJ, Vito O, Patel H, et al. Treatment of multisystem inflammatory syndrome in children. N Engl J Med. 2021 Jul 1;385(1):11–22. Epub 2021 Jun 16.
  12. Son MBF, Murray N, Friedman K, et al. Multisystem inflammatory syndrome in children—initial therapy and outcomes. N Engl J Med. 2021 Jul 1;385(1):23–34. Epub 2021 Jun 16.
  13. Mehta P, Fajgenbaum DC. Is severe COVID-19 a cytokine storm syndrome: A hyperinflammatory debate. Curr Opin Rheumatol. 2021 Sep 1;33(5):419–430.
  14. Nissen CB, Sciascia S, de Andrade D, et al. The role of antirheumatics in patients with COVID-19. Lancet Rheumatol. 2021 Jun;3(6):e447–e459. Epub 2021 Mar 30.
  15. van de Veerdonk FL, Netea MG, van Deuren M, et al. Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome. Elife. 2020 Apr 17;9:e57555.
  16. Kuri-Cervantes L, Pampena MB, Meng W, et al. Comprehensive mapping of immune perturbations associated with severe COVID-19. Sci Immunol. 2020 Jul 15;5(49):eabd7114.
  17. Mathew D, Giles JR, Baxter AE, et al. Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science. 2020 Sep 4;369(6508):eabc8511. Epub 2020 Jul 15.
  18. Wang EY, Mao T, Klein J, et al. Diverse functional autoantibodies in patients with COVID-19. medRxiv. 2021 Feb 1:2020.12.10.20247205. Preprint.

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Filed under:ACR ConvergenceConditionsMeeting ReportsPediatric Conditions Tagged with:ACR Convergence 2021COVID-19Multisystem Inflammatory Syndrome in Children (MIS-C)U.S. Food and Drug Administration (FDA)vaccine hesitancy

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