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Articles by Arthritis & Rheumatology

Enthesitis: New Insights into the Pathogenesis, Diagnostic Modalities & Treatment

Arthritis & Rheumatology  |  February 2, 2016

Enthesitis is a central feature of spondyloarthritis (SpA). This review article summarizes the substantial progress that has been made in addressing the pathophysiology, molecular mechanisms, genetic associations, clinical features, diagnostic modalities and treatment of enthesitis. Further examination into the role of the inflammatory mediators, including IL-17, IL-22, and IL-23 as well as potentially others, in driving enthesitis and bone formation will be important to direct our attention toward future therapeutic targeted pathways in patients with SpA…

2015 ACR Guideline for the Treatment of Rheumatoid Arthritis

Arthritis & Rheumatology  |  November 30, 2015

“Treat to target regardless of disease activity level” tops the list of recommendations for both early and established RA in the 2015 Guideline for the Treatment of Rheumatoid Arthritis. The guideline addresses six major topics, including DMARDs, glucocorticoids and biologics, and includes 74 recommendations. These recommendations are not prescriptive, and the treatment decisions should be made by physicians and patients together…

Low-Grade Inflammation in Symptomatic Knee OA

Arthritis & Rheumatology  |  October 29, 2015

Although osteoarthritis (OA) was formerly considered a non-inflammatory joint disease, it’s now well-appreciated that inflammatory mediators, such as PGE2 and IL-1β, are produced by osteoarthritic joint tissues and can be used to identify patients with symptomatic knee OA. A peripheral blood leukocyte inflammatory transcriptome identifies a subset of symptomatic knee OA patients at higher risk for radiographic progression and may reflect persistent low-grade joint inflammation…

Do Diet & the Environment Induce RA via ACPA Generation?

Arthritis & Rheumatology  |  August 11, 2015

A new study has examined how ACPA may originate at the molecular level. The researchers propose that numerous environmental factors may trigger the generation of ACPAs that then cross-react with various citrullinated human autoantigens through molecular mimicry to induce RA…

International Consensus Statement on the Management & Treatment of IgG4-Related Disease

Arthritis & Rheumatology  |  June 30, 2015

IgG4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory condition that affects multiple organs and can lead to tumefactive, tissue-destructive lesions and organ failure. An international panel of experts has released a consensus statement on its management…

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