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Articles by Arthritis & Rheumatology

Pulmonary Adverse Events with Low-Dose Methotrexate

Arthritis & Rheumatology  |  November 24, 2020

In this large placebo-controlled trial, Sparks et al. examined the predictors and severity of pulmonary adverse events (AEs) in patients taking low-dose MTX. The researchers found that low-dose MTX increased the risk of pulmonary AEs, including possible pneumonitis.

Ticagrelor Lowers the Risk for OA Compared with Clopidogrel

Arthritis & Rheumatology  |  October 28, 2020

Preclinical models have provided important insights into the pathogenesis of OA and potential pathways for therapeutic intervention, including adenosine. Ticagrelor and clopidogrel are both used in patients with coronary artery disease, but only ticagrelor increases extracellular adenosine levels. In this study, treatment with ticagrelor was associated with a 29% lower risk of developing OA than treatment with clopidogrel over five years of follow-up.

RA Patients Taking Either 15 mg or 30 mg Dose of Upadacitinib Experience Improvement

Arthritis & Rheumatology  |  October 1, 2020

The SELECT-EARLY MTX-controlled trial examined the safety and efficacy of upadacitinib, a potent, reversible jakinib, as monotherapy in patients with moderately to highly active RA and poor prognostic features who are either naive for or have limited exposure to methotrexate.

Biologics May Prevent Cardiovascular Events in RA Patients

Arthritis & Rheumatology  |  August 26, 2020

RA patients experience a higher rate of cardiovascular disease (CVD) events than controls. In a new study, Karpouzas et al. determined that current biologic disease-modifying anti-rheumatic drug use is associated with reduced long-term CVD risk, protective calcification of noncalcified lesions and a lower likelihood of new plaque formation in patients with early atherosclerosis.

Lenabasum for Diffuse Cutaneous Systemic Sclerosis

Arthritis & Rheumatology  |  July 27, 2020

In a new study, Spiera et al. assessed the safety and efficacy of lenabasum, a synthetic, orally administered agonist of cannabinoid receptor 2 that modulates the endocannabinoid system to activate the resolution phase of innate immune responses, in diffuse cutaneous systemic sclerosis…

Biosimilar Prescribing Habits in the VA & Academic Settings

Arthritis & Rheumatology  |  June 29, 2020

In a new study, Baker et al. examined reference product and biosimilar orders, comparing data from a Veterans Affairs Medical Center (VAMC) to those from an academic medical center…

Are ANAs More Prevalent in the U.S. Now Than in the Past?

Arthritis & Rheumatology  |  May 28, 2020

According to a new study, the prevalence of anti-nuclear antibodies (ANAs), the most common biomarker of autoimmunity in the U.S., has increased considerably in recent years among adolescents aged 12–19 years, in both sexes (especially in men), older adults (age ≥50 years) and non-Hispanic whites…

Researchers Discuss Viability of Rheumatology Education During the COVID‐19 Pandemic

Arthritis & Rheumatology  |  May 15, 2020

In a matter of weeks, the COVID‑19 crisis has totally upended clinical medicine and the practice of rheumatology. Our old ways of seeing patients in person, precepting fellows in clinic or on the consult service, and leading in-person interactive teaching rounds are gone for now and possibly for good. But how can we replace these…

9/11 Survivors at Increased Risk for Autoimmune Disease

Arthritis & Rheumatology  |  April 30, 2020

Miller-Archie et al. set out to determine whether dust exposure and PTSD are associated with an increased risk of systemic autoimmune disease in a 9/11-exposed cohort not included in previous studies of members of the Fire Department of New York and whether this association differs between 9/11 responders and community members.

A Combined Immunosuppressive Regimen for ILD MDA5-Positive Dermatomyositis

Arthritis & Rheumatology  |  February 27, 2020

Interstitial lung disease accompanied by anti-melanoma differentiation-associated gene 5 positive dermatomyositis is often rapidly progressive and associated with poor prognosis. In this study, a combined immunosuppressive regimen of high-dose glucocorticoids, tacrolimus and intravenous cyclophosphamide proved more effective than treatment with high-dose glucocorticoids and stepwise addition of an immunosuppressant in a historical control group.

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