NEW YORK (Reuters Health)—The osteoporosis drug denosumab is associated with a higher incidence of serious infections compared with placebo, but the risk is similar to comparator drugs, a systematic review and meta-analysis reveals. Talia Diker-Cohen, MD, PhD, of Tel Aviv University, and colleagues searched the literature through May 2019 for randomized controlled trials of denosumab…
Non-Pharmacological Interventions & Management of RA-Related Fatigue
Often, rheumatoid arthritis (RA) patients struggle with fatigue, and the cause of the fatigue remains unclear. Past research suggests RA-related fatigue may be moderately improved by physical activity. A recent narrative review supports these prior findings, noting that patients also benefit moderately from psychosocial interventions…
RA Patients May Be Less Likely to Discontinue Etanercept Than Other TNF Inhibitors
In a systematic literature review, researchers found that rheumatoid arthritis patients taking etanercept were less likely to discontinue their treatment than patients using any of five other tumor necrosis factor inhibitors…
Malignancy Risk Varies with Treatment in Systemic Necrotizing Vasculitis
NEW YORK (Reuters Health)—The risk of malignancy in patients with systemic necrotizing vasculitis varies according to the treatment received, according to an analysis of five randomized controlled trials. Previous studies reported an increased risk of malignancy in patients with systemic necrotizing vasculitis, and a more recent study from the European Vasculitis Study Group, based on…
Off-Label Coverage of Mycophenolate for Scleroderma under Medicare Part D
Based on a request by the ACR Insurance Subcommittee, off-label use of mycophenolate for scleroderma has been added to a Medicare-approved compendium.
EULAR/ACR Criteria Identify SLE in Hospitalized Pericarditis Patients
NEW YORK (Reuters Health)—New European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria can be used to identify patients with systemic lupus erythematosus (SLE) in an unselected group of patients hospitalized for pericardial effusion, new findings show.1 “Overall, in patients with pericardial effusion and positive ANA, the diagnosis of SLE could be ruled out…
Tears of Knee Ligaments & Meniscus Carry Highest Arthritis Risk
(Reuters Health)—Young adults who have had knee injuries are much more likely than uninjured peers to develop knee osteoarthritis (OA) by middle age, especially if they have broken bones or torn connective tissue, a recent study suggests. Cruciate ligament injuries were associated with a 19.6% greater risk of knee osteoarthritis, the study found. Meniscal tears…
New ACR/EULAR IgG4 Classification Criteria Introduced
Immunoglobulin G4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic and pathologic data is required for diagnosis. ACR/EULAR classification criteria for IgG4-RD have now been developed and validated in a large cohort of patients…
Baby on Board: The Rheumatologist’s Role in Family Planning for Patients with Lupus
For patients with lupus, family planning discussions are vital to achieving positive pregnancy outcomes & maintaining overall health…
Immunoassay May Help Identify Pediatric Lyme Arthritis
NEW YORK (Reuters Health)—In Lyme disease-endemic areas, a C6 peptide enzyme immunoassay (EIA) test may help guide initial management of children with acute arthritis, an observational study suggests.1 “Children with Lyme disease frequently present to the emergency department with an inflamed joint,” Lise Nigrovic, MD, MPH, of Boston Children’s Hospital tells Reuters Health by email….
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