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Subcategories:Axial SpondyloarthritisClinical Criteria/GuidelinesGout and Crystalline ArthritisMyositisOsteoarthritis and Bone DisordersOther Rheumatic ConditionsPain SyndromesPediatric ConditionsPsoriatic ArthritisRheumatoid ArthritisSjögren’s DiseaseSoft Tissue PainSystemic Lupus ErythematosusSystemic SclerosisVasculitis

Silent Cardiac Impairment in SLE

Arthritis & Rheumatology  |  

Drug-naive, new-onset SLE patients, even those with inactive disease, are likely to have silent cardiac impairment, according to a new study by Guo et al. Cardiac involvement is the leading cause of death in patients with lupus, and the estimates of cardiac impairment in SLE range from 31–70%. Cardiac impairment can remain unrecognized until after autopsy. These researchers investigated the use of cardiac MRI to explore early warning signs of silent cardiac involvement in SLE and determine treatment timing…

Cerebral Blood Flow Variability May Provide Insights into Fibromyalgia

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Recent research demonstrated that fibromyalgia patients have lower cerebral blood flow velocity variability than healthy controls, which may reflect impaired coordination of cerebral regulatory systems. This analysis may be a promising tool for characterizing fibromyalgia pathology and understanding health-related quality of life…

Sputum Antibody Response in People at Risk for RA

Catherine Kolonko  |  

Researchers say a study of individual antibody response to citrullinated and non-citrullinated proteins in sputum samples further supports the importance of the lung in early development of rheumatoid arthritis-related autoimmunity. Investigation of the fundamental mechanism that leads to antibody responses in rheumatoid arthritis is key to uncovering ways to predict and prevent the development of…

Pediatric Lupus Outcomes: Researchers Follow Kids into Adulthood

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A study published in the May issue of Arthritis Care & Research may be the first to examine the long-term outcomes of childhood-onset lupus, otherwise known as pediatric systemic lupus erythematosus (SLE), a chronic, multisystem autoimmune disease with a highly variable clinical course. Previous studies examined cross-sectional views of damage accrued. According to the Childhood…

The Burden of Rheumatic Diseases Among Indigenous People in Latin America Is Disproportionate

David C. Holzman  |  

Indigenous communities in Latin America lack good healthcare—and often lack any healthcare—for musculoskeletal and rheumatic diseases.1 Global health initiatives tend to focus on infectious disease, despite the increasing rate of chronic diseases. In a survey of 6,155 individuals from eight indigenous communities, conducted by a team of Latin American investigators, the prevalence of these conditions…

Phase 2 Results for Mavrilimumab Are In

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Recent data showing sustained, long-term safety and efficacy of mavrilimumab for the treatment of rheumatoid arthritis (RA) confirm and build on prior evidence from phase 2 studies of the potential for this new agent for the treatment of RA. Mavrilimumab is a human monoclonal antibody that blocks a proinflammatory cytokine involved in RA pathogenesis—granulocyte-macrophage colony-stimulating…

Identifying Cardiovascular Risk Factors in Psoriatic Arthritis

Larry Beresford  |  

Psoriatic arthritis (PsA), like other inflammatory diseases, has been associated with increased incidence for and mortality from cardio­vascular disease (CVD), the most common comorbidity leading to death in many conditions treated by rheumatologists. But beyond recognizing the burden of increased inflammation, the mechanisms behind this association are not well understood, says M. Elaine Husni, MD,…