Various drugs are known to cause musculoskeletal symptoms, such as arthralgias, myalgias, drug-induced lupus and serum sickness.1 In the rheumatology world, the most commonly recognized drugs that can cause musculoskeletal symptoms are hydralazine, minocycline, fluoroquinolones and, recently, the dipeptidyl peptidase 4 (DPP-4) inhibitor class of medications. Although beta blockers also have a noted side effect…
Sialendoscopy Enhances Salivary Flow in Sjogren’s Syndrome
NEW YORK (Reuters Health)—Sialendoscopy with irrigation of the major salivary glands can enhance salivary flow and reduce xerostomia in patients with Sjogren’s syndrome, according to a randomized trial. “In our study it is suggested that patients with recent onset of Sjogren’s syndrome and with residual salivary gland capacity could benefit from sialendoscopy,” said Dr. Derk…
Ixekizumab Promising for AS; Plus Certolizumab Pegol Studied for Psoriasis
In a Phase 3 study, ixekizumab proved safe and effective to treat adults with ankylosing spondylitis (AS)…
Younger Patients Getting Knees & Hips Replaced
NEW YORK (Reuters Health)—Patients undergoing total joint replacement are younger now than they were in 2000, new research indicates. The average patient undergoing a total hip replacement (THR) in 2014 was 64.9 years, while the average patient in 2000 was 66.3 years. Similarly, the average patient undergoing a total knee replacement (TKR) was 65.9 in…
Study Finds Newer Gout Drug Poses Risk to Heart Patients
(Reuters Health)—Gout sufferers with major pre-existing heart disease face a higher risk of death if they are treated with the drug febuxostat, a large long-term study has concluded. The risk of death from cardiovascular disease was 34% higher with febuxostat than with allopurinol. When researchers considered deaths from any cause, the risk was 22% higher…
Periodontitis May Provide Insight into RA
Researchers explored the role of carbamylated protein (CarP) and neutrophil extracellular traps (NETs) in periodontitis and rheumatoid arthritis (RA). The results showed significantly higher levels of CarP and NETs in patients with both RA and periodontitis than in healthy controls. The data suggest that RA and periodontitis may share an underlying pathogenic mechanism…
Opioids No Better Than NSAIDs for Chronic Back or Arthritis Pain
(Reuters Health)—Acetaminophen, ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) are better than opioids at easing the intensity of chronic pain in the back, knees or hips, a U.S. experiment suggests. And opioids are no better than these other drugs at reducing how much pain interferes with daily activities, such as walking, working, sleeping or enjoying…
Inflammation in OA: Signs & Treatment Opportunities
The demonstrated connection between persistent effusion-synovitis and cartilage damage in certain osteoarthritis (OA) patients has implications for targeted treatment that updates previous OA treatment parameters…
Lyme Disease Spreads Through Ontario
New research highlights the current geographic areas of Ontario, Canada, associated with Lyme disease and the presence of Ixodes scapularis. The study found the ticks are expanding their range at a rate of 46–55 km/year, with several sites showing the presence of Borrelia burgdorferi, which causes Lyme disease. These findings may help target public health interventions in the areas at greatest risk…
Healthy Diet Linked to Lower Hip Fracture Risk in U.S. Women
(Reuters Health)—Eating an overall healthy diet is tied to a lower risk of hip fracture among women over age 50, a U.S. study suggests. Researchers analyzed decades’ worth of dietary and health data for more than 100,000 U.S. men and women. They found that women who scored highest on the American Healthy Eating Index-2010 (AHEI)…
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