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Systemic Sclerosis

Cilnidipine Receives Orphan Drug Status to Treat Systemic Sclerosis

Michele B. Kaufman, PharmD, BCGP  |  May 9, 2025

Based on research showing improved signs and symptoms of systemic sclerosis in patients taking cilnidipine vs. placebo, the FDA granted orphan drug designation for the agent.

Can Stem Cell Transplantation Improve Survival Rates in Patients with Systemic Sclerosis?

Arthritis & Rheumatology  |  April 30, 2025

Autologous hematopoietic stem cell transplantation (AHSCT) may improve the survival rate of patients with diffuse cutaneous systemic sclerosis (SSc), according to Georges et al. The single-arm clinical trial demonstrated the effectiveness of AHSCT and maintenance therapy. Researchers also identified potential risk factor of AHSCT in patients with low eGFR before transplantation.

Experts Discuss Guidelines for Interstitial Lung Disease in Systemic Autoimmune Rheumatic Disease

Ruth Jessen Hickman, MD  |  March 6, 2025

Over 50% of patients with systemic sclerosis (SSc) develop interstitial lung disease (ILD), and rheumatologists have long recognized this major cause of morbidity and mortality.1 Sindhu R. Johnson, MD, PhD, professor of medicine at the University of Toronto, Canada, and director of the Toronto Scleroderma Program, notes that more recent studies have increased our awareness…

Skin disorder, pepper appearance from scleroderma, autoimmune disease male hand Skin disorder pepper appearance from vitiligo,scleroderma raynaud, medical concept autoimmune disease. Credit: Adobe Stock | Trsakaoe

Through Thick & Thin: Updates in Scleroderma

Jason Liebowitz, MD, FACR  |  January 22, 2025

Pulmonary hypertension and Raynaud’s phenomenon are just some of the symptoms patients with systemic sclerosis (SSc) may experience. Here are insights into the diagnosis and management of SSc.

Precision Medicine Benefits Patients with Systemic Sclerosis

Jason Liebowitz, MD, FACR  |  November 26, 2024

Experts provided insights into how precision medicine is being used to address the needs and care of patients with systemic sclerosis.

Diagnosing Skin Disease in Patients with Dark Skin

Thomas R. Collins  |  November 23, 2024

Many rheumatologists may not be trained to properly identify the signs of skin disease in patients with dark skin, but in this ACR Convergence session, experts provide practical guidance for diagnosis.

3 AC&R Study Summaries: Lupus Fog, SSc Variance By Ethnicity & Tuberculosis Screening in New DMARD Users

Arthritis Care & Research  |  August 7, 2024

Lupus Fog? By Laura C. Plantinga, PhD, Patricia P. Katz, PhD, S. Sam Lim, MD, MPH, C. Barrett Bowling, MD, MSPH, & Jinoos Yazdany, MD, MPH Why was this study done? Perceived cognitive impairment (i.e., lupus fog) is common in systemic lupus erythematosus (SLE). However, comprehensive, multidomain assessments of objective cognitive function are rarely performed….

Editor's Pick

The ACR and CHEST Release 2 New ILD Guidelines

Ruth Jessen Hickman, MD  |  July 9, 2024

Clinicians should not rely on glucocorticoids as a first-line treatment of SARD-ILD in patients with systemic sclerosis, according to a strong recommendation in a new ILD treatment guideline from the ACR and CHEST. The guideline is one of two addressing the screening, monitoring and treatment of patients with interstitial lung disease (ILD) secondary to systemic autoimmune rheumatic diseases (SARDs).

The Future of SLE Treatment?

Ruth Jessen Hickman, MD  |  January 22, 2024

Georg Schett, MD, presented the latest research into CAR T cell therapy for rheumatic diseases, such as systemic lupus erythematosus & other conditions. These findings demonstrate remarkable and durable efficacy for the treatment, as well as the potential for disease remission in some patients.

Small Fiber Neuropathy for the Rheumatologist

Michael Cammarata, MD  |  January 10, 2024

Small fiber neuropathy is a common form of peripheral neuropathy with multiple potential etiologies and a varied clinical presentation. It can’t be detected by nerve conduction studies, making it an elusive and often overlooked entity. Small fiber neuropathy is well documented in several rheumatic diseases, and its symptom burden can profoundly affect quality of life….

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