CHICAGO—In the basic science session, Beyond NETs: Alternative Roles of Neutrophils in Spondyloarthritis, neutrophils are explored as a common pathophysiologic thread among the spondyloarthropathies. In this two-part talk, Dennis McGonagle, PhD, professor of investigative rheumatology at the Leeds Institute of Rheumatic and Musculoskeletal Medicine at St James Hospital, Leeds, England, opens by examining the role…

Meeting Management Challenges in axSpA
At this ACR Convergence 2025 session, experts discussed emerging concepts with axial spondyloarthritis, including the most effective MRI specifications for diagnosis, challenges with axial juvenile spondyloarthritis & the many mimics of axSpA.

Insights from an Orthopedic Spine Surgeon
Dr. Jay Reidler, an adult & pediatric orthopedic spine surgeon, shares insights from his field & discusses his collaborations with rheumatologists.

Reactive Arthritis: Chronic or Self-Limiting?
Reactive arthritis has proved to be a diagnostic & therapeutic challenge due to its diverse presentations.
Chronic Back Pain & axSpA
Maksymowych et al. assessed the frequency of axial spondyloarthritis (axSpA) according to extra-articular presentation and human leukocyte antigen B27 (HLA-B27) status and sought to identify features that distinguish patients with axSpA from those with non-specific back pain. Their data support recommendations that patients with chronic back pain and extra-articular features related to axSpA be screened for axSpA with MRI and referred to a rheumatologist.

FDA Approves Bimekizumab-bkzx (Bimzelx) for 3 New Rheumatic Indications
The FDA has approved bimekizumab-bkzx for the treatment of adults with psoriatic arthritis, non-radiographic axial spondyloarthritis and ankylosing spondylitis.

An Approach to Physical Activity & Exercise in Axial Spondyloarthritis
‘Physical therapy is a mainstay of managing rheumatic diseases, but what’s the evidence, how do we monitor, and what types of therapy should we advocate?’ asks Physician Editor Bharat Kumar, MD, MME, FACP, FAAAAI, RhMSUS. ‘Here, we provide some practical recommendations for the everyday rheumatologist.’ Physical activity, including occupational and recreational activities, is one of…

Key Research in Axial Spondyloarthritis Encapsulated
Our understanding of (axSpA) has really changed, especially with regard to male-female differences. In this report, we identify important research on axSpA presented at ACR Convergence 2024, summarize the abstracts and comment on why each is important, addressing the relevance for clinicians and the potential impact on future research.

Are Sacroiliac Joint MRIs Accurate in Routine Clinical Practice?
Hadsbjerg et al. compared assessments of sacroiliac joint MRIs in local MRI reports from routine care in five European countries with re-reads by central experts in patients with a diagnosis of axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) to estimate the extent of over- or under-reporting of features and misclassification.

Approaches to Difficult-to-Manage Spondyloarthritis
At this ACR Convergence 2024 session, two experts spoke about identifying difficult-to-manage patients with spondyloarthritis, differentiating active disease from fibromyalgia & therapy selection in these patients.
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