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Other Rheumatic Conditions

How to Improve Oral & Eye Health in Sjögren’s Patients

Vanessa Caceres  |  March 15, 2021

ACR CONVERGENCE 2020—Sjögren’s syndrome requires care from several specialists, and presenters at the Sjögren’s Syndrome: Dental and Ocular Perspectives session shared diagnostic and treatment pearls from their respective specialties.  Rebecca Manno, MD, MHS, of the Comprehensive Arthritis and Rheumatology Center of the U.S. Virgin Islands moderated the session.  Oral Health Dry mouth is famously associated…

Case Report: A Non-Tuberculous Mycobacterial Infection

Bradley Bohman, MD, & Jawad Bilal, MBBS  |  January 20, 2021

Tumor necrosis factor-α inhibitors (TNFi’s) have emerged as an integral part of therapeutic strategies for several rheumatic diseases. TNF-α is a pro-inflammatory cytokine implicated in the pathogenesis of rheumatoid arthritis (RA), seronegative spondyloarthropathies and inflammatory bowel disease (IBD). It also plays a central role in the immune response to mycobacterial infection.  Many biologic agents, particularly…

Dana Robochek / shutterstock.com

VEXAS: A Newly Identified & Vexing Myeloid-Driven Inflammation

Bryn Nelson, PhD  |  December 14, 2020

A large, international team of rheumatologists, geneticists, hematologists and other researchers has discovered a severe inflammatory syndrome linked to an acquired genetic mutation in the bone marrow of older men. The X-linked syndrome, they found, is caused by a somatic mutation in myeloid stem cells that hobbles the master regulator of a pathway tasked with…

ACR Convergence graphic

Antiphospholipid Syndrome: Management & Future Directions

Lara C. Pullen, PhD  |  December 4, 2020

Three experts discuss recent developments in the diagnosis & treatment of APS & the future direction of research.

2020 Pediatric Rheumatology Research in Review

Carina Stanton  |  November 24, 2020

ACR CONVERGENCE 2020—This has been a busy year for research publications covering a number of pediatric rheumatic diseases, including the emerging multi-system inflammatory syndrome (MIS-C) associated with SARS CoV-2. Despite the many challenges brought about by the COVID-19 pandemic, a healthy collection of publications covering a wide range of pediatric rheumatology research topics were published…

Anti-TNF Treatment Trial Encouraging for High-Risk APS Pregnancies

Thomas R. Collins  |  November 19, 2020

Early results in a phase 2 trial are finding that adding a TNF blocker to other treatment could greatly lower the risk of serious complications during pregnancy for women who have antiphospholipid syndrome with lupus anticoagulant.

Can We Predict & Prevent Pregnancy Complications in Patients with Lupus & APS?

Thomas R. Collins  |  November 13, 2020

ACR CONVERGENCE 2020—New evidence, though derived from small numbers, suggest that treatment with the TNF-inhibitor certolizumab could help improve high-risk pregnancy outcomes in women with antiphospholipid syndrome (with or without systemic lupus erythematosus) and lupus anticoagulants, an expert said. In the Phase 2 IMPACT trial, which has already enrolled 27 women and is continuing to…

Study: DPP4 Inhibitors Yield Promise for Systemic Sclerosis Treatment

Ruth Jessen Hickman, MD  |  November 12, 2020

A recent paper in Arthritis & Rheumatology opens up the possibility of a new research avenue to treat systemic sclerosis: dipeptidyl peptidase 4 (DPP4) inhibitors, a previously approved therapy for type 2 diabetes.1 Work in mouse models and on skin samples from systemic sclerosis patients suggests these drugs pose a promising area of future translational…

Mattew - Bilder und mehr / shutterstock.com

Yao Syndrome: A Case Report & Clinical Review

Peter Gorevic, MD, & Qingping Yao, MD, PhD  |  November 12, 2020

Case Presentation History of present illness A 66-year-old white woman presented with unexplained, recurrent episodes of high fever, abdominal pain, rash and arthralgias occurring over the previous three years. During typical episodes, the patient experienced flu-like symptoms, followed by fever, abdominal pain and non-bloody diarrhea without tenesmus. Her temperatures were 101–103ºF, with chills lasting up…

ACR Convergence 2020 Kicks Off: Plenary session speakers highlight racial differences in lupus & COVID-19-related findings

Ruth Jessen Hickman, MD  |  November 7, 2020

ACR CONVERGENCE 2020—The ACR’s first fully virtual annual meeting kicked off on Thursday, Nov. 5. During the Opening Session, ACR President Ellen M. Gravallese, MD, talked about how the specialty’s response during the pandemic has provided great hope and will help rheumatology become an even more essential specialty. At the first Plenary Session on Friday,…

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