Test Your HLA Polymorphism Proficiency From the College | June 27, 2024 A particular human leukocyte antigen (HLA) is known to cause reactions to allopurinol. Updated recommendations from the  2020 ACR Guideline for the Management of Gout  include testing some populations for this polymorphism before starting allopurinol, due to the higher prevalence of this gene in these populations. For more key points from the guideline, review our article, or take the quiz first. Which of the following HLA polymorphisms is associated with allopurinol hypersensitivity reactions? A. HLA-DR4*0401 B. HLA-B*5701 C. HLA-B*5801 D. HLA-B*1502 None Time's up
