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Ethics Forum: Pediatric Vaccination Refusals Raise Challenges for Physicians

Emily von Scheven, MD, MAS  |  April 13, 2016

The boy who could not walk: S.L. is a previously healthy 10-year-old boy who has not walked for three months. Physical examination reveals swollen wrists, knees, ankles and several toes. There is reduced hip range of motion and flexion contractures of both knees. He can stand with assistance, but is unable to take a single…

Filed under:ConditionsEthicsPediatric ConditionsPractice SupportProfessional Topics Tagged with:autismdeclineEthicsPatientsPediatricPhysiciansRheumatic Diseaserheumatologistvaccination

From the Expert: Don’t Forget to Vaccinate Immuncompromised Patients

Richard Quinn  |  April 8, 2016

Preventing infection in immunocompromised patients is challenging, especially with the increased use of biologic treatments, which have been known to reactivate latent infections, such as the herpes zoster virus. Nicolas Issa, MD, discusses recent vaccination research and prevention techniques to help this patient group avoid infection…

Filed under:Conditions Tagged with:BiologicsherpesInfectionpreventionvaccination

Mediterranean Diet Tied to Lower Hip Fracture Risk

Andrew M. Seaman  |  March 29, 2016

(Reuters Health)—Women who maintain an overall healthy diet may benefit from a slightly reduced risk of hip fractures later in life, according to a new U.S. study. Women who followed a Mediterranean-style diet were about three tenths of a percent less likely to break a hip over about 16 years, compared to women who didn’t…

Filed under:ConditionsOsteoarthritis and Bone Disorders Tagged with:DieteatingFractureshiphip fracturehip fracture riskMediterranean dietOsteoporosis

Researchers Find the Switch that Underlies Macrophage Metabolism

Lara C. Pullen, PhD  |  March 28, 2016

During pro-inflammatory stimulation, a recent study found HIF1α—not Myc—is required for the regulation of glycolysis in macrophages. Researchers examined macrophages and the distinct transcriptional programs engaged in response to mitogenic and pro-inflammatory stimulation…

Filed under:ConditionsResearch Rheum Tagged with:inflammationmacrophagesmetabolism

Knowledge of Genetic Risk Doesn’t Prompt Behavior Changes

Kathryn Doyle  |  March 23, 2016

(Reuters Health)—Telling patients about their genetic risk for disease doesn’t usually lead to healthy behavior changes, such as eating better or exercising more, according to a new analysis of existing studies. Researchers selected 18 studies that tracked seven potential behavior changes—such as quitting smoking, diet, physical activity and using sun protection—among people who had received…

Filed under:Conditions Tagged with:behaviorbehavior changegenetic riskgenetic testPatients

U.S. Agency Issues New Guidelines to Limit Chronic Use of Opioids

Ransdell Pierson  |  March 18, 2016

(Reuters)—Addressing a growing “epidemic” of opioid overdoses and abuse of the prescribed painkillers in the U.S., the Centers for Disease Control and Prevention on Tuesday released voluntary guidelines that instruct primary care doctors to sharply deter use of the medicines for chronic pain. “Overprescribing opioids, largely for chronic pain, is a key driver of America’s…

Filed under:AnalgesicsConditionsDrug UpdatesPain Syndromes Tagged with:Centers for Disease Control and PreventionChronic painGuidelinesOpioids

Diagnosis Can Be Elusive for Fever of Unknown Origin

Diagnosis Can Be Elusive for Fever of Unknown Origin

Charles Radis, DO  |  March 15, 2016

Settling into room 501 at Maine Medical Center, Mrs. N was on her way to the bathroom when she felt it coming on. One moment she was okay; the next, her chest felt damp and cold, even as her face flushed and her temperature spiked. Her forehead glistened beads of warm sweat. She felt the…

Filed under:Conditions Tagged with:Diagnosisfeverpatient careprodromeRheumatic DiseaseRheumatoid arthritisrheumatologistSarcoidosis

Respiratory-Related Mortality Higher in Men with RA

Catherine Kolonko  |  March 15, 2016

A study that found men with rheumatoid arthritis (RA) died from respiratory-related illness nearly three times as often as the general population could provide insight into possible treatment options and lifestyle changes that would help them live longer. The Study Researchers at the Veterans Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical…

Filed under:ConditionsRheumatoid Arthritis Tagged with:chronic obstructive pulmonary disorderCOPDillnesslung diseasemenmortalityrespiratoryRheumatoid arthritisrisk

2015 ACR/ARHP Annual Meeting: Genetic Links Emerge in Osteoarthritis

Thomas R. Collins  |  March 15, 2016

SAN FRANCISCO—As researchers have delved into the genetics behind osteoarthritis (OA), genes that appear to be players in the disease have emerged, but there have also been curveballs thrown, with expectations not always matching up to the genetic realities, an expert said at the 2015 ACR/ARHP Annual Meeting. The genetic risk of acquiring OA is…

Filed under:ConditionsMeeting ReportsOsteoarthritis and Bone DisordersResearch Rheum Tagged with:2015 ACR/ARHP Annual MeetingAmerican College of Rheumatology (ACR)geneticslinkOsteoarthritisResearch

2015 ACR/ARHP Annual Meeting: Skin Issues in Rheumatic Diseases Present Challenges

Thomas R. Collins  |  March 15, 2016

SAN FRANCISCO—A 40-year-old woman shows up in the clinic with scarring alopecia, with an area of hyperpigmentation on the rim of her scalp, extending from just behind the temple to behind her ears. An examination with a dermatoscope shows hyperkeratotic follicular plugging. The case—in this example, the discoid form of cutaneous lupus erythematosus (DLE)—is one…

Filed under:ConditionsMeeting ReportsMyositisResearch RheumSystemic Lupus Erythematosus Tagged with:2015 ACR/ARHP Annual MeetingAmerican College of Rheumatology (ACR)dermatitisDermatologydermatomyositisDiagnosisImmunologyLupusResearchRheumatic DiseaseskinSLEsubacute cutaneous lupus erythematosus

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