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Filgotinib Promising for RA

Michele B. Kaufman, PharmD, BCGP  |  August 26, 2019

Research shows filgotinib may be safe and effective for treating rheumatoid arthritis. The drug’s manufacturer is expected to be submit a new drug application for filgotinib to the FDA in 2019…

Filed under:Drug Updates Tagged with:filgotinibMethotrexateRheumatoid Arthritis (RA)

Shingles Vaccine Not the Only Immunization Linked with Gout Flare

Marilynn Larkin  |  August 21, 2019

NEW YORK (Reuters Health)—The recombinant shingles vaccine (RZV) is associated with an increased risk of gout flare, and a new study suggests other vaccines may trigger flares as well, researchers say. “Our findings are novel because for the first time, we have identified a trigger for gout flares that presumably acts through [an inflammatory] pathway,…

Filed under:ConditionsGout and Crystalline Arthritis

Improved Pregnancy Outcomes for Women with SLE

Lara C. Pullen, PhD  |  August 19, 2019

Recent research indicates that previous concerns about mortality associated with pregnancy in women with SLE may no longer be applicable. In the study, researchers found a significant decline in the in-hospital maternal mortality rate of women with SLE and a decrease in their length of non-delivery related hospitalization over the past two decades…

Filed under:ConditionsSystemic Lupus Erythematosus Tagged with:Outcomespregnancypregnancy complicationspregnant womenSLEsystemic lupus erythematosus (SLE)

Otilimab Begins Phase 3 Clinical Studies for RA

Michele B. Kaufman, PharmD, BCGP  |  August 19, 2019

In a four-part clinical trial program, researchers are assessing the safety and efficacy of otilimab with placebo in RA patients, along side conventional treatments, such as tofacitinib, and DMARDs…

Filed under:Drug Updates Tagged with:biologic DMARDsotilimabRheumatoid Arthritis (RA)sarilumab

Recent Awards & Appointments in Rheumatology

Gretchen Henkel  |  August 16, 2019

Prestigious Carol Nachman Prize for Research in Rheumatology Awarded to Ellen Gravallese On May 10, Ellen M. Gravallese, MD, the Myles J. McDonough Chair in Rheumatology and chief of the Division of Rheumatology at University of Massachusetts Medical School, Worcester, was awarded the prestigious Carol Nachman Prize for lifetime achievement in rheumatology research in Wiesbaden,…

Filed under:AwardsProfiles Tagged with:Carol Nachman PrizeDr. Alfred H.J. KimDr. Alysia KwiatkowskiDr. Ellen M. GravalleseLupus Leadership Award

Case Report: Not All Crystals Are Gout

Katherine Yates, MD, Erin H. Penn, MD, & Minna J. Kohler, MD   |  August 16, 2019

Patients with chronic kidney disease (CKD) often experience joint pain due to various etiologies, including crystalline arthropathies, renal osteodystrophy, amyloid arthropathy, erosive osteoarthritis, avascular necrosis and even erosive spondylarthrosis.1 Below, we present a case of crystalline arthropathy in a patient with chronic kidney disease, mistaken for gout. The Case A 29-year-old man was admitted to…

Filed under:ConditionsGout and Crystalline Arthritis Tagged with:chronic kidney diseasecrystal arthropathiesGout

Case Report: RA Patient Suffers Methotrexate-Induced Cutaneous Lesions

Nitasha Kumar, MD  |  August 16, 2019

Methotrexate (MTX) remains the predominant medication used by rheumatologists to treat rheumatoid arthritis (RA). Doses of 7.5–25 mg per week with daily folic acid are generally prescribed. Despite its common use, MTX must be prescribed cautiously given the potential adverse effects when taken incorrectly or without folic acid supplementation. Cases of MTX-induced cutaneous ulceration have…

Filed under:ConditionsRheumatoid Arthritis Tagged with:Methotrexatetoxicity

Lessons from Master Clinicians: An Interview with Dr. Gail Kerr

Jason Liebowitz, MD, FACR  |  August 16, 2019

Many, if not all, rheuma­tologists seek to grow as clinicians so they can provide consistently exceptional care to patients and serve as role models for colleagues and trainees. In this series, Lessons from a Master Clinician, we compile insights from clinicians who have achieved a level of distinction in the field of rheumatology. Gail Kerr,…

Filed under:Career DevelopmentEducation & TrainingProfessional Topics Tagged with:DiversityDr. Gail Kerrgender balanceinequalityLessons from Master Clinicianspatient historyphysical examRole Models in Rheumatology

This chest CT shows new left upper lobe groundglass opacity.

Case Report: Could Myocarditis + Shortness of Breath = EGPA?

Ambreesh Chawla, MD, Ashwini Komarla, MD, & Sujatha Vuyyuru, MD  |  August 16, 2019

Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome or allergic granulomatosis and angiitis, is a rare small- and medium-vessel vasculitis. This disease was first described by American pathologists Jacob Churg and Lotte Strauss in 1951.1 Although the vasculitis is often not apparent in the initial phases of the disease, EGPA can affect any…

Filed under:Conditions Tagged with:eosinophilic granulomatosis with polyangiitis (EGPA)myocarditis

New Studies Identify Possible Markers of Early Systemic Sclerosis

Bryn Nelson, PhD  |  August 16, 2019

Although the true cause of systemic sclerosis (SSc), or scleroderma, remains unknown, researchers have made progress in detecting the autoimmune disease’s early presence. Beyond the physiological signs of Raynaud’s phenomenon, a capillaroscopy can detect alterations in microcirculation and lab tests can confirm the presence of telltale autoantibodies, such as anti-topoisomerase 1, anti-centromere and anti-RNA polymerase…

Filed under:ConditionsResearch RheumSystemic Sclerosis Tagged with:inflammatory markersmacrophagesystemic sclerosis (SSc)

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