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After COVID-19-Associated MIS-C, Immune Changes Resolve

Marilynn Larkin  |  

NEW YORK (Reuters Health)—A new study of multisystem inflammatory syndrome in children (MIS-C) shows that the immune system is profoundly altered during acute illness, but gradually returns back to normal. MIS-C is distinct from both COVID-19 and Kawasaki disease, but is associated with previous SARS-CoV-2 infection, the immunological profiling study reveals. Dr. Manu Shankar-Hari, an…

Biologics May Prevent Cardiovascular Events in RA Patients

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RA patients experience a higher rate of cardiovascular disease (CVD) events than controls. In a new study, Karpouzas et al. determined that current biologic disease-modifying anti-rheumatic drug use is associated with reduced long-term CVD risk, protective calcification of noncalcified lesions and a lower likelihood of new plaque formation in patients with early atherosclerosis.

Advocacy 101 Teaches Legislative, Advocacy Basics

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Bharat Kumar, MD, Advocacy 101 coordinator and Government Affairs Committee member, describes the virtual program designed to educate and empower rheumatology fellows in training, program directors and ARP members to advocate for issues that affect rheumatology practices and patients in advance of the Advocates for Arthritis that will take place virtually in September.

Rheum After 5: Dr. Eric Matteson Writes Rheumatic Disease History

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Over the past 20 years, Eric L. Matteson, MD, MPH, emeritus chair, Division of Rheumatology, and emeritus professor of medicine at the Mayo Clinic College of Medicine and Science, Rochester, Minn., as well as a past president of the Rheumatology Research Foundation, has authored or co-authored six books about the history of rheumatic disease and…

How to Create a Safe Practice & Prep for a COVID-19 Resurgence

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For many months, the healthcare world has been significantly affected by the swift and per­vasive effects of SARS-CoV-2, which causes COVID-19. The virus has severely affected the delivery of patient care by all providers, including those in hospitals and emergency care settings, who grappled with the response to massive influxes of COVID-19 patients, and those…

Figure 1A–C: Arrows denote hemophagocytic histiocytes.

Case Report: Too Many Activated Immune Cells in a 9-Month-Old Boy

Jeffrey Lo, MD  |  

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease of immune dysregulation characterized by unchecked inflammatory responses leading to end-organ dysfunction. Primary HLH results from inherited mutations that impair the capacity for immune regulation; secondary HLH arises from the inappropriate response to an immune stimulus, such as infection, malignancy or autoimmunity. What is less well known is…

Case Report: What’s Causing This Severe Case of Rhabdomyolysis?

Aditya S. Pawaskar, MBBS, MD, & Weishali V. Joshi, MD  |  

Rhabdomyolysis is a clinical syndrome characterized by muscle tissue necrosis and release of intramuscular components into the circulation. Typical manifestations include muscle pain and myoglobinuria, causing dark urine. Serum creatinine kinase (CK) enzyme levels are usually markedly elevated. Severity can range from muscle enzyme elevation in the serum of an otherwise asymptomatic patient to extremely…

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ACR Releases COVID-19 & MIS-C Clinical Guidance for Kids with Rheumatic Disease

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The ACR has released clinical guidance documents for pediatric patients with rheumatic disease in the context of the COVID-19 pandemic, including one for multi-system inflammatory syndrome in children (MIS-C). Jay Mehta, MD, MS, an attending physician in the Division of Rheumatology and director of the Pediatric Rheumatology Fellowship at the Children’s Hospital of Philadelphia (CHOP),…