NEW YORK (Reuters Health)—The prevalence of antinuclear antibodies (ANA) in the blood of U.S. adolescents and adults has increased over the past 30 years, signaling a rise in autoimmunity, researchers say. “It is not known if these same increases are occurring in other parts of the world, but because ANA are associated with many autoimmune…
Study Finds ANA-Negative Classification Errors Among Newly Diagnosed Lupus Patients
How laboratories define a serological hallmark of systemic lupus erythematous and which assays they use to detect it could contribute to misclassification of patients identified as anti-nuclear antibody (ANA) negative, according to researchers. Most people who have lupus test positive for ANAs as part of an immunology screening for autoimmune disorders. The presence of ANAs…
Laboratory Testing for Diagnosis, Management of Patients with Rheumatic Disease
A review of data on antinuclear antibodies and tests for rheumatoid arthritis
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Some Lupus Tests Yield False Results
The ACR’s Regional Advisory Council (RAC) has received several member reports of false results on antinuclear antibody (ANA) tests. The test screens for systemic lupus erythematosus, drug-induced lupus, and other diseases. Results are used to direct treatment, so accuracy is crucial.