Reuters)—Severe COVID-19 may trick the immune system into producing autoantibodies that have the potential to eventually attack healthy tissue and cause inflammatory diseases, researchers warned in a paper published in Nature Communications.1 They found autoantibodies in blood samples from roughly 50% of the 147 COVID-19 patients they studied, but in fewer than 15% of 41…
COVID-19 & Pediatric Rheumatology
PRSYM 2021—Although primary COVID-19 infection has the most significant complications in adult patients, pediatric rheumatologists have also seen significant changes in their practice over the past year. With the emergence of COVID-19, the rise of a mysterious post-COVID hyperinflammatory syndrome, now known as multisystem inflammatory syndrome in children (MIS-C), was identified, and pediatric rheumatologists have…
Case Report: Reactive Arthritis Following COVID-19
SARS-CoV-2, or COVID-19, is a complex disease entity that continues to evolve. Physicians, researchers and scientists alike have worked tirelessly to tackle this beast in its short existence; however, we are reminded daily that there is more to this virus than meets the eye. It is well known that COVID-19 can cause acute respiratory failure…
A Look Back at the ACR’s Strong Response to COVID-19
We are now a year-and-a-half into the COVID‑19 pandemic, and rheumatologists and rheumatology professionals are still facing some of the same challenges that began in spring 2020, as well as new ones. Most recently, we learned that COVID‑19 vaccine efficacy is reduced in some patients on immunosuppressive therapies and the need for additional immunization is…
Moonshot: Apollo 11, Vaccines & Other Conspiracies
On July 20, 1969, at 10:56 p.m. EDT, American astronaut Neil Armstrong stepped off the lunar landing module, Eagle, and walked on the moon.1 Or so they would have you believe. For most, the basic facts are not in dispute: On May 25, 1961, President John F. Kennedy delivered a speech to a joint session…
COVID-19 Disproportionately Stymies Women Researchers
The COVID-19 pandemic changed pretty much every facet of human activity, from home life to social interactions to the workplace. Medicine and research kept up a dizzying pace throughout the pandemic, with physicians and researchers working clinic hours even if they were able to use telemedicine to do some of their work from home. For…
COVID-19 Vaccination Induces T Cell Response in Patients Treated with Rituximab
Research indicates mRNA vaccination for SARS‐CoV‐2 infection may induce a T cell response in vulnerable, immunocompromised patient populations being treated with rituximab.
ACR Guidance on Tocilizumab Allocation During Shortage
In June, the U.S. Food & Drug Administration (FDA) issued an emergency use authorization (EUA) for tocilizumab (Actemra) for treatment of hospitalized COVID-19 adults and children who are receiving systemic corticosteroids and supplemental oxygen. Since this announcement, the tocilizumab manufacturer, Genentech, has not been able to produce enough product to meet the higher demand. The…
NIH Starts Study of COVID-19 Booster Shot in People with Autoimmune Diseases
(Reuters)—The U.S. National Institutes of Health (NIH) is testing a booster shot of COVID-19 vaccines in people with autoimmune diseases who have not responded well to the primary vaccine course. The mid-stage study will be conducted among about 600 participants aged 18 and above who have been fully vaccinated with shots from either Pfizer Inc.,…
COVID-19 Vaccine Efficacy & Safety Discussed at Town Hall
At a recent ACR town hall, panelists described immune responses and side effects of COVID-19 vaccination in patients with rheumatic disease, along with ways to leverage monoclonal antibody treatments, especially in light of virus variants.
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