A recent Arthritis & Rheumatology review article explores the immune system’s mechanism for creating B cells that respond to diverse pathogens while preserving immune tolerance & highlights key insights for rheumatologists.
Researchers have identified a unique population of entheseal resident cells that can be activated by interleukin 23 (IL-23). This finding may be key to understanding how dysregulation of IL-23 results in precise inflammation of the entheses.