A recently published study shows that inflammatory disease begins well before synovitis is seen on exam; a better understanding of what’s brewing before the storm could lead to the development of preventive therapies for RA.
What Rheumatologists Should Know About B Cell Tolerance & Autoimmunity
A recent Arthritis & Rheumatology review article explores the immune system’s mechanism for creating B cells that respond to diverse pathogens while preserving immune tolerance & highlights key insights for rheumatologists.
T Cells & Autoimmune Diseases
New investigational strategy provides way to identify, characterize autoreactive T cells that escape thymic selection and cause autoimmunity
TNF-α Impairs Regulatory T Cells in Patients with Rheumatoid Arthritis
When researchers treated patients with RA with TNF-α–specific antibody, they were able to restore Treg cell function. (posted June 3, 2013)
Neutralizing IL-23 and Its Targets May Improve Ankylosing Spondylitis
Researchers have identified a unique population of entheseal resident cells that can be activated by interleukin 23 (IL-23). This finding may be key to understanding how dysregulation of IL-23 results in precise inflammation of the entheses.
T Cells in Systemic Lupus Erythematosus
Progress toward targeted therapy
A&R Abstracts – T CELLS
For Further Reading
Th 17 Cells and Arthritis
The true story of how IL-17 became a focus for RA research
Th17 Cells Explained
The new kids on the block have rheumatologic ramificatons