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Articles tagged with "Tet2"

High-Salt Diet May Trigger Gene Silencing & a Lupus Phenotype

Lara C. Pullen, PhD  |  August 15, 2016

New research has demonstrated that a high-salt diet may increase the differentiation of follicular helper T cells (Tfh). A high-salt diet also increased lupus features in MRL/lpr mice, suggesting that the genes that increased expression in response to salt intake were similar to the genes that had increased expression in lupus CD4+ T cells…

Study Uncovers Tet2’s Role in Resolving Inflammation

Lara C. Pullen, PhD  |  January 11, 2016

When investigating the role of epigenetic modifiers in inflammatory response, researchers found that Tet2 acts at the chromatin level to help resolve inflammation in both dendritic cells and macrophage, repressing the transcription of IL-6…

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