The Rheumatologist
COVID-19 News
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
      • Gout Resource Center
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Resource Centers
    • Ankylosing Spondylitis Resource Center
    • Gout Resource Center
    • Rheumatoid Arthritis Resource Center
    • Systemic Lupus Erythematosus Resource Center
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
    • Electronic Health Records
    • Apps
    • Information Technology
    • From the College
    • Multimedia
      • Audio
      • Video
  • Resources
    • Issue Archives
    • ACR Convergence
      • Systemic Lupus Erythematosus Resource Center
      • Rheumatoid Arthritis Resource Center
      • Gout Resource Center
      • Abstracts
      • Meeting Reports
      • ACR Convergence Home
    • American College of Rheumatology
    • ACR ExamRheum
    • Research Reviews
    • ACR Journals
      • Arthritis & Rheumatology
      • Arthritis Care & Research
      • ACR Open Rheumatology
    • Rheumatology Image Library
    • Treatment Guidelines
    • Rheumatology Research Foundation
    • Events
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / 2013 ACR/ARHP Annual Meeting: Rheumatology Year in Review

2013 ACR/ARHP Annual Meeting: Rheumatology Year in Review

December 1, 2013 • By Mary Beth Nierengarten

  • Tweet
  • Email
Print-Friendly Version / Save PDF

He emphasized again that these studies, particularly the pediatrics trials, show what can be achieved with large collaborative networks working together on these challenging questions. “With very few exceptions, the work that I highlight [in this session] required collaboration and trust among many investigators,” he said. “Very little of this work could have been accomplished at a single site or even a small handful of sites.”

You Might Also Like
  • 2013 ACR/ARHP Annual Meeting: Better Care for Pediatric Rheumatology Patients On Horizon
  • 2013 ACR/ARHP Annual Meeting: Researchers Explore Role of Pathogens, Quality of Care in Rheumatoid Arthritis
  • 2013 ACR/ARHP Annual Meeting: Inflammatory Eye Disease Management Can Benefit from Collaboration between Rheumatologists and Ophthalmologists
Explore This Issue
December 2013
Also By This Author
  • For RA Patients, Functional Disability May Precede Diagnosis

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE
Five Rheumatology Drugs with New Indications
click for large version
Table 1: Five Rheumatology Drugs with New Indications

Basic Science Perspective: Moving Toward Personalized Medicine

Steven R. Goldring, MD, chief scientific officer and St. Giles Chair of the Hospital for Special Surgery and professor of medicine at Weill Cornell Medical College in New York, N.Y., touched on several areas of research over the past year that are helping to further refine an understanding of the disease mechanisms and pathophysiology of rheumatic diseases. Among this research is ongoing inquiry into identifying new molecules and pathways that hold promise for developing more effective and specific therapies for rheumatic diseases. He cited a number of studies looking at targeting the interleukin 23 pathway for treatment of ankylosing spondylitis and psoriatic arthritis, the use of lubricin to slow the progression of osteoarthritis, and targeting the Wnt pathway for treatment of fibrosing disorders such as scleroderma.5-7

These studies show what can be achieved with large collaborative networks working together.

He also talked about the huge databases generated by two parallel collaborative projects, ENCODE and the NIH Roadmap Epigenomics Mapping Consortium, and the daunting task of applying the information from these databases to understanding disease mechanisms and biological and clinical processes. He highlighted examples of recent studies that are already beginning to address these needs, such as, “a study that has identified a generic variant (SNP) that controls the level of disease activity in rheumatoid arthritis and Crohn’s disease, and a study that has identified the potential role of epigenetic modifications in DNA structure in the pathogenesis and activation of disease flares in patients with systemic lupus.” 8,9

Dr. Goldring emphasized that information from the genomic and epigenetic studies is beginning to provide important insights into disease mechanisms and pathophysiology. “These insights also hold the promise of providing biomarkers that can be used to direct patient care, predict outcomes, and provide insights into disease mechanisms that can be used to select optimal patient treatments,” he said.


Mary Beth Nierengarten is a freelance medical journalist based in St. Paul, Minn.

ad goes here:advert-3
ADVERTISEMENT
SCROLL TO CONTINUE

References

  1. Katz JN, Brophy RH, Chaisson CE, et al. Surgery versus physical therapy for a meniscal tear and osteoarthritis. N Engl J Med. 2013; 368:1675-1684.
  2. O’Dell JR, Mikuls TR, Taylor TH, et al. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med. 2013;369:307-318.
  3. O’Dell JR, Curtis JR, Mikuls TR, et al. Validation of the methotrexate-first strategy in patients with early, poor-prognosis rheumatoid arthritis: Results from a two-year randomized, double-blind trial. Arthritis Rheum. 2013;65:1985-1994.
  4. Specks U, Merkel PA, Seo P, et al. Efficacy of remission-induction regimens for ANCA-associated vasculitis. N Engl J Med. 2013;369:417-427.
  5. Sherlock JP, Joyce-Shaikh B, Turner SP, et al. IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. Nat Med. 2012;18:1069-1076.
  6. Ruan MZ, Erez A, Guse K, et al. Proteoglycan 4 expression protects against the development of osteoarthritis. Sci Transl Med. 2013;5:176ra34.
  7. Akhmetshina A, Palumbo K, Dees C, et al. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun. 2012;3:735.
  8. Lee JC, Espéli M, Anderson CA, et al. Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway. Cell. 2013; 155:57-69.
  9. Absher DM, Li X, Waite LL, et al. Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genetics. 2013;9:e1003678.

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

Pages: 1 2 3 4 | Single Page

Filed Under: Conditions, Drug Updates, Meeting Reports, Rheumatoid Arthritis Tagged With: clinical trials, Disease, Pediatric, review, rheumatology, targeted therapy, TreatmentIssue: December 2013

You Might Also Like:
  • 2013 ACR/ARHP Annual Meeting: Better Care for Pediatric Rheumatology Patients On Horizon
  • 2013 ACR/ARHP Annual Meeting: Researchers Explore Role of Pathogens, Quality of Care in Rheumatoid Arthritis
  • 2013 ACR/ARHP Annual Meeting: Inflammatory Eye Disease Management Can Benefit from Collaboration between Rheumatologists and Ophthalmologists
  • 2013 ACR/ARHP Annual Meeting: The Rheumatoid Arthritis Treatment Debate

American College of Rheumatology

Visit the official website for the American College of Rheumatology.

Visit the ACR »

ACR Convergence

Don’t miss rheumatology’s premier scientific meeting for anyone involved in research or the delivery of rheumatologic care or services.

Visit the ACR Convergence site »

Simple Tasks

Learn more about the ACR’s public awareness campaign and how you can get involved. Help increase visibility of rheumatic diseases and decrease the number of people left untreated.

Visit the Simple Tasks site »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2021 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.