The de-methylation process and the gain of 5hmC might offer a therapeutic window, she said.
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Recent findings raise the possibility of, “whether by modulating the DNA methylation and de-methylation dynamics, we can actually change or modulate OA pathology.”
“A broader idea is just to also think about the OA epigenome—the mapping of the OA epigenome—even beyond DNA methylation changes, and to figure out the target genes of these genomic changes and to identify whether the modulation of the OA epigenome, per se, can be a new therapeutic strategy for OA.”
Thomas R. Collins is a medical writer based in Florida.
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