Now, in conjunction with a pharmaceutical company, her lab is in search of small molecules that inhibit the activity of Schnurri-3 to prevent its bone-mass-reducing effects. Using specially designed assays, they hope to find several such molecules.
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“Within a few months,” she said, there will hopefully be “more to say about what some of those molecules might be.”
Thomas R. Collins is a medical writer based in Florida.
- Jones DC, Wein MN, Oukka M, et al. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science. 2006 May 26;312(5777):1223–1227.
- Wein MN, Jones DC, Shim JH, et al. Control of bone resorption in mice by Schnurri-3. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8173–8178.