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NASP Reduces Tophi in Uncontrolled Gout

Michele B. Kaufman, PharmD, BCGP  |  January 16, 2026

A post-hoc analysis of data from two clinical trials showed that nano-encapsulated sirolimus with pegylated-adricase (NASP) may be effective for promoting tophus resolution and lowering serum uric acid in patients with uncontrolled gout.

FDA Approves Obinutuzumab for Lupus Nephritis

Michele B. Kaufman, PharmD, BCGP  |  January 13, 2026

Based on data from multiple clinical trials, the FDA has approved obinutuzumab for the treatment of adults with lupus nephritis in combination with standard therapy.

Dr. Samantha Shapiro, six months post-op: Sunrise at Annapurna Base Camp, Nepal.

Hip Replacements at 14,000 Feet: A Joint Doctor with Joint Disease, Part 2

Samantha C. Shapiro, MD  |  January 13, 2026

Dr. Sam Shapiro writes about her recovery from total hip arthroplasty, detailing what “recovering well with no post-operative complications” really meant and her experience hiking in the Himalayas with a new hip.

Clinical Manifestations of VEXAS

Arthritis & Rheumatology  |  January 13, 2026

Anderson et al. studied genetic data on more than 190,000 participants and found 23 who had genetic variants in the UBA1 gene, which is associated with VEXAS.

RA Research Presented at ACR Convergence 2025 in Focus

Jeffrey Curtis, MD, MS, MPH  |  January 9, 2026

This synopsis of research into rheumatoid arthritis highlights key areas presented at ACR Convergence 2025, including strategies to delay or prevent RA, emerging mechanisms of action in RA treatment, and the growing role of AI in advancing RA research and clinical care.

The Promise of Hope in Lupus Nephritis

Colin B. Ligon, MD, MHS  |  December 9, 2025

Explore the latest lupus nephritis advances in this supplement, covering CAR-T therapy, obinutuzumab data & new diagnostic tools.

Insights into SLE & Lupus Nephritis From the 2025 Review Course

Jason Liebowitz, MD  |  December 7, 2025

Review expert strategies & clinical pearls for managing SLE & lupus nephritis. Get therapeutic updates from the ACR’s 2025 Review Course.

Lupus Nephritis: A Serious Manifestation of Systemic Lupus Erythematosus

Graciela S. Alarcón, MD, MPH, MACR  |  December 6, 2025

This review highlights some of the many abstracts on lupus nephritis research presented at ACR Convergence 2025. They demonstrate advances made on early recognition of the condition, as well as offering some hope in terms of achieving better outcomes.

Reflections on B Cells in SLE & Lupus Nephritis

Ruth Jessen Hickman, MD  |  December 5, 2025

At the Dubois Memorial Lecture presented at ACR Convergence 2025, Shaun Jackson, MD, PhD, discussed the evolving understanding of the role of B cells in SLE.

Hydroxychloroquine Remains a Mainstay in Lupus Nephritis

Shivani Garg, MD, PhD  |  December 3, 2025

New data: HCQ reduces risk of eGFR decline by 61–73% & slows kidney function loss. Early initiation is critical for renal health in lupus nephritis.

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