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You are here: Home / Articles / AbbVie’s RA Drug Succeeds in Late Stage Study

AbbVie’s RA Drug Succeeds in Late Stage Study

June 11, 2018

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(Reuters)—Abbvie Inc. says its experimental drug met the main goal of halting progression of moderate to severe rheumatoid arthritis (RA) in a late-stage trial.

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The drug, upadacitinib, was tested as a monotherapy in patients who have not been treated with chemotherapy agent methotrexate.

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Upadacitinib, which belongs to a class of drugs known as JAK inhibitors, also helped improve symptoms of the disease such as swollen joint counts, the company says, adding it plans to submit a U.S. marketing application in the second half of 2018.

AbbVie, whose drug Humira is the market-leading treatment for RA, is among drugmakers developing JAK inhibitors, which work by blocking inflammation-causing enzymes known as Janus kinases.

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Last week, the U.S. Food and Drug Administration approved lower doses of another JAK inhibitor developer by Eli Lilly and Incyte Corp, but gave it a label that analysts said could restrict its potential for use in a larger population.

Filed Under: DMARDs & Immunosuppressives, Drug Updates Tagged With: Rheumatoid Arthritis (RA), upadacitinib

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