It has long been known that hyperlipidemia adversely affects bone, but the exact pathologic mechanism(s) underlying hyperlipidemia-induced bone loss has not been fully understood. Until now.
Pathogenesis of Osteoporosis
New research by Ambrogini and colleagues shows that oxidation-specific epitopes derived from lipid peroxidation contribute to the pathogenesis of osteoporosis.1 Importantly, the research shows that innate immune antibodies against these epitopes can offer a protective effect against the disease—at least in mice.
“There are antibodies against oxidized phospholipids that are protective against osteoporosis,” says lead author of the study, Elena Ambrogini, MD, PhD, assistant professor, Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and Central Arkansas Veterans HealthCare System, directed by Stavros C. Manolagas, MD, PhD, in Little Rock, Ark. “We have shown in mice that if you overexpress these antibodies, the mice have more bone.”