Autoantibodies Against LINE-1 p40 May Be More Common in Patients with Active SLE

Vanessa Caceres is a medical writer in Bradenton, Fla.

References

Carter V, LaCava J, Taylor MS, et al. High prevalence and disease correlation of autoantibodies against p40 encoded by long interspersed nuclear elements in systemic lupus erythematosus. Arthritis Rheumatol. 2020 Jan;72(1):89–99.
Crow MK. Long interspersed nuclear elements (LINE-1): Potential triggers of systemic autoimmune disease. Autoimmunity. 2010 Feb;43(1):7–16.
Mavragani CP, Sagalovskiy I, Guo Q, et al. Long interspersed nuclear element-1 retroelements are expressing in patients with systemic autoimmune disease and induce type 1 interferon. Arthritis Rheumatol. 2016 Nov;68(11):2686–2696.
Crow MK. Reactivity of IgG with the p40 protein encoded by the long interspersed nuclear element 1 retroelements: Comment on the article by Carter et al. Arthritis Rheumatol. 2020 Feb;72(2):374–376.

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