The Rheumatologist
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
  • Technology
    • Electronic Health Records
    • Apps
    • Information Technology
  • Resources
    • Issue Archives
    • Events
    • Multimedia
      • Audio
      • Video
    • From the College
    • American College of Rheumatology
    • Rheumatology Research Foundation
    • Arthritis & Rheumatology
    • Arthritis Care & Research
    • Treatment Guidelines
    • Research Reviews
    • Annual Meeting
      • Abstracts
      • Meeting Reports
    • Rheumatology Image Bank
    • ACR ExamRheum
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / Benefits of Secukinumab in Ankylosing Spondylitis May Persist at 2 Years

Benefits of Secukinumab in Ankylosing Spondylitis May Persist at 2 Years

January 17, 2017 • By Reuters Staff

  • Tweet
  • Email
Print-Friendly Version / Save PDF

NEW YORK (Reuters Health)—Secukinumab appears to improve clinical and radiographic outcomes of ankylosing spondylitis (AS) through two years of therapy, according to new results from the MEASURE 1 study.

You Might Also Like
  • Clinical Trials Confirm Secukinumab Can Effectively Treat Ankylosing Spondylitis
  • Rheumatology Drug Updates: Abaloparatide Promising for Osteoporosis, Plus Secukinumab for Ankylosing Spondylitis
  • Abaloparatide Promising for Osteoporosis; NICE Draft Guidelines Include Secukinumab for Ankylosing Spondylitis

Secukinumab is a fully human monoclonal antibody against interleukin-17A, which is implicated in various pathophysiological features of spondyloarthritis.

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE

In a report online Dec. 13 in the Annals of the Rheumatic Diseases, Dr. Juergen Braun from Rheumazentrum Ruhrgebiet in Heme, Germany, and colleagues present an update on the efficacy and safety of secukinumab in patients with AS during the continuation phase of MEASURE 1 through two years of therapy.

Among patients who remained on secukinumab treatment through Week 104, Assessment of SpondyloArthritis international Society 20 (ASAS20) and ASAS40 rates were 73.7% and 55.7%, respectively, among patients receiving 150 mg intravenous secukinumab and 68.0% and 48.5% in those receiving the 75 mg dose.

ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE

Response rates were higher in anti-TNF-naïve patients than in patients who previously had an inadequate response to or had stopped treatment with anti-TNF agents for safety or tolerability reasons, though both groups experienced significant improvements.

Improvements were also observed in total Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and all other secondary endpoints at Week 104.

Radiographs scored using the modified Stoke Ankylosing Spondylitis Spine Score showed sustained improvements at 104 weeks, with more than 80% of patients showing no spinal radiographic progression.

ad goes here:advert-3
ADVERTISEMENT
SCROLL TO CONTINUE

Discontinuations of secukinumab due to adverse effects were infrequent, and the incidence of serious adverse effects was low.

“These longitudinal results from MEASURE 1 demonstrate that secukinumab provides similar levels of improvement in the clinical signs and symptoms of AS at two years as those previously reported during the short-term placebo-controlled period and provide the first uncontrolled data on spinal radiographic progression in patients with AS under treatment with an IL-17A inhibitor,” the researchers conclude.

“Long-term controlled studies are needed to evaluate whether secukinumab inhibits the progression of structural manifestations of AS,” they add.

Novartis Pharma AG sponsored the trial, employed three of the authors and had various relationships with several others.

Dr. Braun could not be reached for comments.


Reference

  1. Braun J, Baraliakos X, Deodhar A, et al. Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study. Ann Rheum Dis. 2016 Dec 13. pii: annrheumdis-2016-209730. doi: 10.1136/annrheumdis-2016-209730. [Epub ahead of print]

Filed Under: DMARDs & Immunosuppressives, Drug Updates Tagged With: ankylosing spondyl­itis, clinical trial, secukinumab, Spondylarthritis

You Might Also Like:
  • Clinical Trials Confirm Secukinumab Can Effectively Treat Ankylosing Spondylitis
  • Rheumatology Drug Updates: Abaloparatide Promising for Osteoporosis, Plus Secukinumab for Ankylosing Spondylitis
  • Abaloparatide Promising for Osteoporosis; NICE Draft Guidelines Include Secukinumab for Ankylosing Spondylitis
  • Ixekizumab Improves Outcomes of Ankylosing Spondylitis

Simple Tasks

Learn more about the ACR’s public awareness campaign and how you can get involved. Help increase visibility of rheumatic diseases and decrease the number of people left untreated.

Visit the Simple Tasks site »

Rheumatology Research Foundation

The Foundation is the largest private funding source for rheumatology research and training in the U.S.

Learn more »

American College of Rheumatology

Visit the official website for the American College of Rheumatology.

Visit the ACR »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2019 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.