Biomarkers Differentiate Crohn's Disease from Ulcerative Colitis - Page 2 of 2

“A more profound problem than distinguishing UC from CD is to accurately phenotype a patient in a manner that predicts disease course, response to therapy and risk of complications. Genetic studies have highlighted a shared and distinct pathophysiology that exists between UC and CD, but have largely been disappointing with respect to predicting clinical outcomes for patients,” he notes.

Like the authors, Dr. Cohen is optimistic that the newly identified biomarkers “in future, longitudinal studies may provide the type of clinical information that not only distinguishes UC from CD, but actually predicts patient outcomes more accurately.”

The study had no commercial funding, and the authors declared no competing interests.

A 42-year-old man with a history of ulcerative colitis (UC), primary sclerosing cholangitis (PSC) and chronic sinusitis was referred to a rheumatologist to evaluate for a possible diagnosis of systemic vasculitis. This patient had developed new skin lesions, gingival hypertrophy and ulcerating tracheobronchitis, concerning for possible granulomatosis with polyangiitis (GPA). Since 1994, the patient had…

Patients with autoimmune diseases, such as spondyloarthritis, are at risk of developing inflammatory bowel disease. Here are considerations for its management and treatment.

NEW YORK (Reuters Health)—Fluctuations in the gut microbiome over time could underlie inflammatory bowel disease (IBD), including Crohn’s and ulcerative colitis, researchers suggest. “Both the state and the dynamics of the human gut microbiome in healthy individuals are highly personalized. Although cross-sectional studies have revealed dysbiosis of the gut microbiome in IBD, little is known…

NEW YORK (Reuters Health)—Serum biomarkers can discriminate between Crohn’s disease (CD) and ulcerative colitis (UC), according to Danish and Dutch researchers. “The biomarker assays measure neo-epitopes, which are fragments of extracellular matrix protein degradation,” Joachim Høg Mortensen, a PhD student at Nordic Bioscience in Herlev, Denmark, told Reuters Health by email. ad goes here:advert-1ADVERTISEMENTSCROLL TO…

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