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MADRID—Researchers have found that systemic lupus erythematosus (SLE) is independently linked with bipolar disorder and say the findings point to a need for greater awareness of psychiatric problems in patients with SLE.
In work led by investigators at Tel Aviv University in Israel and presented at the 2017 Annual European Congress on Rheumatology (EULAR), researchers analyzed data from the medical database of Clalit Health Services, which includes a chronic disease registry with continuous real-time input. The study included data for 5,018 SLE patients and 25,090 matched controls.1
Investigators found a higher prevalence of bipolar disorder among SLE patients than among controls—0.62% vs. 0.26% (P<0.001). In a multivariate analysis, SLE was found to be independently associated with the disorder, with an odds ratio of 1.74 (P=0.012).
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