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Case Report: CPPD Presenting as Pseudosepsis

Hassan Fakhoury, BS, Erin Chew, MD, & Narender Annapureddy, MBBS  |  Issue: September 2022  |  September 6, 2022

It is important to underscore the clinician’s responsibility to always rule out infection while pursuing other possible etiologies. High index of suspicion for CPPD is needed in patients older than 65, even in light of other data that may be mistakenly interpreted as evidence of septic joint, including a high synovial WBC count, absence of chondrocalcinosis and improvement on antibiotics, as we observed in our patient.


Hassan Fakhoury, BS, is a student at Vanderbilt University School of Medicine, Nashville, Tenn.

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Erin Chew, MD, is a fellow in the Department of Rheumatology, Vanderbilt University Medical Center, Nashville, Tenn.

Narender Annapureddy, MBBS, is an associate professor of medicine, Department of Rheumatology, Vanderbilt University Medical Center, Nashville, Tenn.

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References

  1. Rosenthal AK, Ryan LM. Calcium pyrophosphate deposition disease. N Engl J Med. 2016 June 30;374(26):2575–2584.
  2. McCarty DJ. Calcium pyrophosphate dihydrate crystal deposition disease—1975. Arthritis Rheum. 1976 May-Jun;19 Suppl 3:275–285.
  3. Gordon C, Swan A, Dieppe P. Detection of crystals in synovial fluids by light microscopy: Sensitivity and reliability. Ann Rheum Dis. 1989 Sep;48(9):737–742.
  4. Oppermann BP, Cote JK, Morris SJ, Harrington T. Pseudoseptic arthritis: A case series and review of the literature. Case Rep Infect Dis. 2011;2011:942023.
  5. Paul P, Paul M, Dey D, et al. Pseudoseptic arthritis: An initial presentation of underlying psoriatic arthritis. Cureus. 2021 Apr 24;13(4):e14660.
  6. Eberst-Ledoux J, Tournadre A, Mathieu S, et al. Septic arthritis with negative bacteriological findings in adult native joints: A retrospective study of 74 cases. Joint Bone Spine. 2012 Mar;79(2):156–159.
  7. Margaretten ME, Kohlwes J, Moore D, Bent S. Does this adult patient have septic arthritis? JAMA. 2007 Apr 4;297(13):1478–1488.
  8. Zhang W, Doherty M, Bardin T, et al. European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: Terminology and diagnosis. Ann Rheum Dis. 2011 Apr;70(4):563–570.

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Filed under:ConditionsGout and Crystalline Arthritis Tagged with:calcium pyrophosphate deposition diseaseGoutpseudosepsisseptic arthritis

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