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Case Report: What’s Causing This Severe Case of Rhabdomyolysis?

Aditya S. Pawaskar, MBBS, MD, & Weishali V. Joshi, MD  |  Issue: August 2020  |  August 12, 2020


Aditya S. Pawaskar, MBBS, MDAditya S. Pawaskar, MBBS, MD, is a rheuma­tology fellow at the University of Connecticut School of Medicine, Farmington. Dr. Pawaskar earned his medical degree from Lokmanya Tilak Municipal Medical College, Mumbai, India. He completed residency training in internal medicine at Westchester Medical Center of New York Medical College.

Weishali V. Joshi, MDWeishali V. Joshi, MD, is the section chief of rheumatology at Trinity Health of New England Medical Group, Saint Francis Hospital and Medical Center, Hartford, Conn. Dr. Joshi earned her medical degree from Grant Medical College, Mumbai. She completed residency training in internal medicine, as well as her rheumatology fellowship, at the University of Connecticut.

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References

  1. Hekimsoy Z, Oktem IK. Serum creatine kinase levels in overt and subclinical hypothyroidism. Endocr Res. 2005;31(3):171–175.
  2. Madariaga MG. Polymyositis-like syndrome in hypothyroidism: Review of cases reported over the past twenty-five years. Thyroid. 2002 Apr;12(4):331–336.
  3. Monzani F, Caraccio N, Siciliano G, et al. Clinical and biochemical features of muscle dysfunction in subclinical hypothyroidism. J Clin Endocrinol Metab. 1997 Oct; 82(10):3315–3318.
  4. Sekine N, Yamamoto M, Michikawa M, et al. Rhabdomyolysis and acute renal failure in a patient with hypothyroidism. Intern Med. 1993 Mar;32(3):269–271.
  5. Scott KR, Simmons Z, Boyer PJ. Hypothyroid myopathy with a strikingly elevated serum creatine kinase level. Muscle Nerve. 2002 Jul;26(1):141–144.
  6. Finsterer J, Stöllberger C, Grossegger C, Kroiss A. Hypothyroid myopathy with unusually high serum creatine kinase values. Horm Res. 1999;52(4):205–208.
  7. Halverson PB, Kozin F, Ryan LM, Sulaiman AR. Rhabdomyolysis and renal failure in hypothyroidism. Ann Intern Med. 1979 Jul;91(1):57–58.
  8. Riggs JE. Acute exertional rhabdomyolysis in hypothyroidism: The result of a reversible defect in glycogenolysis? Mil Med. 1990 Apr;155(4):171–172.
  9. Kiernan TJ, Rochford M, McDermott JH. Simvastatin induced rhabdomyolysis and an important clinical link with hypothyroidism. Int J Cardiol. 2007 Jul 31;119(3):374–376.
  10. Antons KA, Williams CD, Baker SK, Phillips PS. Clinical perspectives of statin-induced rhabdomyolysis. Am J Med. 2006 May;119(5):400–409.
  11. Hochberg MC, Koppes GM, Edwards CQ, et al. Hypothyroidism presenting as a polymyositis-like syndrome. Report of two cases. Arthritis Rheum. 1976 Nov–Dec;19(6):1363–1366.
  12. Eslamian F, Bahrami A, Aghamoham­madzadeh N, et al. Electrophysiologic changes in patients with untreated primary hypo­thyroidism. J Clin Neurophysiol. 2011 Jun;28(3):323–328.
  13. Mastaglia FL, Ojeda VJ, Sarnat HB, Kakulas BA. Myopathies associated with hypothyroidism: A review based upon 13 cases. Aust N Z J Med. 1988 Oct;18(6):799–806.

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Filed under:Conditions Tagged with:hypopituitarismhypothyroidismrhabdomyolysis

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