The investigators then evaluated soluble forms of CD89, CD64 and CD16A to identify which of these receptors might have an active role in treatment response. They found elevated sCD64 was specific for RA and was not found in a reference group of patients with active psoriatic arthritis.
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“With this study, we want to draw the attention to CD64 as an important player in early autoantibody positive RA,” write the authors in the discussion. “In our analyses, no other membrane-bound FcγRs were found significantly modified, and sCD64 was elevated only in RA plasma. The early naive RA monocytes were characterized by up-regulation of CD64 and membrane bound IgG.”
Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
- Matt P, Lindqvist U, Kleinau S. Elevated membrane and soluble CD64: A novel marker reflecting altered FcγR function and disease in early rheumatoid arthritis that can be regulated by anti-rheumatic treatment. PLoS One. 2015 Sep 25;10(9):e0137474. doi: 10.1371/journal.pone.0137474. eCollection 2015.