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You are here: Home / Articles / Centrexion’s Chili-Based Painkiller Offers Relief for 6 Months—Study

Centrexion’s Chili-Based Painkiller Offers Relief for 6 Months—Study

June 14, 2017 • By Natalie Grover

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(Reuters)—A synthetic version of a medicine traditionally extracted from chili plant relieved knee pain among osteoarthritis patients for up to six months, data showed, bringing Centrexion Therapeutics a step closer to developing a safe and effective analgesic.

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The drug, designed to be injected at the site of pain, is being developed by the privately-held company run by former Pfizer Inc chief executive Jeffrey Kindler.

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Centrexion’s drug, a man-made version of chili plant extract trans-capsaicin, is designed to work by inactivating local pain fibers transmitting signals to the brain.

The mid-stage trial tested two doses of the drug, CNTX-4975, against a placebo in 175 difficult-to-treat knee osteoarthritis patients who had failed or were unable to tolerate prior pain therapy.

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Data showed the drug induced statistically significant pain relief as well as reduced knee stiffness and improved physical function at 24 weeks after a single injection.

Patients on the 1 milligram (mg) dose experienced a reduction of 3.8 on a scale measuring daily pain with walking, versus a decline of 2.4 for those on the placebo, the company said.

With exploding U.S. rates of abuse, overdose and addiction to opioids – a lethal family of drugs widely prescribed for pain – as well as side-effects seen with other pain treatments, developing an analgesic with little side-effects has become imperative.

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The safety profile of CNTX-4975 was comparable to that of a placebo, chief medical officer Randall Stevens said, adding that the medicine is cleared out of the body 24 hours after it is injected.

“When you eat a hot chili meal, you’re consuming about 25 mg of capsaicin. So the systemic exposure from the meal is actually higher,” he told Reuters.

The Boston-based company, which is developing various non-opioid painkillers, expects to initiate a late-stage study later this year for CNTX-4975.

The drug is also being evaluated to treat patients with Morton’s neuroma pain as well as canine osteoarthritis.

Filed Under: Drug Updates, Osteoarthritis Tagged With: Centrexion, chili plant, Chili-Based Painkiller, CNTX-4975, knee pain

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