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Curbside Consults: Experts Weigh in on Complex Rheumatic Conditions

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“There seems to be a steroid-responsive switch in patients with AIED [in which] high TNF levels seen experimentally correlated with steroid sensitivity; whereas high IL-1 levels seen experimentally were associated with clinical steroid-resistance,” she said

Thomas Collins is a freelance medical writer based in Florida.

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References

  1. Fagni F, Bettiol A, Talarico R, et al. Long-term effectiveness and safety of secukinumab for treatment of refractory mucosal and articular Behçet’s phenotype: A multicentre study. Ann Rheum Dis. 2020 Aug;79(8):1098–1104.
  2. Karacayli U, Mumcu G, Simsek I, et al. The close association between dental and periodontal treatments and oral ulcer course in behcet’s disease: A prospective clinical study. J Oral Pathol Med. 2009 May;38(5):410–415.
  3. Cohen S, Shoup A, Weisman MH, et al. Etanercept treatment for autoimmune inner ear disease: Results of a pilot placebo-controlled study. Otol Neurotol. 2005 Sep;26(5):903–907.
  4. Van Wijk F, Staecker H, Keithley E, et al. Local perfusion of the tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss. Audiol Neurootol. 2006;11(6):357–365.
  5. Pathak S, Stern C, Vambutas A. N-Acetylcysteine attenuates tumor necrosis factor alpha levels in autoimmune inner ear disease patients. Immunol Res. 2015 Dec;63(1–3):236–245.

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