The Rheumatologist
  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed
  • Home
  • Conditions
    • Rheumatoid Arthritis
    • SLE (Lupus)
    • Crystal Arthritis
    • Spondyloarthritis
    • Osteoarthritis
    • Soft Tissue Pain
    • Scleroderma
    • Vasculitis
    • Systemic Inflammatory Syndromes
    • Guidelines
  • Drug Updates
    • Biologics & Biosimilars
    • DMARDs & Immunosuppressives
    • Topical Drugs
    • Analgesics
    • Safety
    • Pharma Co. News
  • Professional Topics
    • Ethics
    • Legal
    • Legislation & Advocacy
    • Career Development
      • Certification
      • Education & Training
    • Awards
    • Profiles
    • President’s Perspective
    • Rheuminations
  • Practice Management
    • Billing/Coding
    • Quality Assurance/Improvement
    • Workforce
    • Facility
    • Patient Perspective
  • Technology
    • Electronic Health Records
    • Apps
    • Information Technology
  • Resources
    • Issue Archives
    • Events
    • Multimedia
      • Audio
      • Video
    • From the College
    • American College of Rheumatology
    • Rheumatology Research Foundation
    • Arthritis & Rheumatology
    • Arthritis Care & Research
    • Treatment Guidelines
    • Research Reviews
    • Annual Meeting
      • Abstracts
      • Meeting Reports
    • Rheumatology Image Bank
    • ACR ExamRheum
  • About Us
    • Mission/Vision
    • Meet the Authors
    • Meet the Editors
    • Contribute to The Rheumatologist
    • Subscription
    • Contact
  • Advertise
  • Search
You are here: Home / Articles / Emerging Treatments for OA: New Therapies Target Joint Pain, Not Just Structural Damage

Emerging Treatments for OA: New Therapies Target Joint Pain, Not Just Structural Damage

November 28, 2018 • By Susan Bernstein

  • Tweet
  • Email
Print-Friendly Version / Save PDF

Susan Bernstein is a freelance medical journalist based in Atlanta.

You Might Also Like
  • Secukinumab Inhibits Structural Joint Damage in Active PsA
  • Nonsurgical Therapies for Knee OA Pain: From Medications to Bracing to Exercise, What Works & What Doesn’t
  • Nonsurgical Treatments Can Relieve Pain, Improve Hand Function in Thumb Carpometacarpal Joint Osteoarthritis
Explore This Issue
January 2019
Also By This Author
  • Arthritis Crisis: It’s Time to Act

References

ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE
  1. Loeser RF, Goldring SR, Scanzello CR, et al. Osteoarthritis: A disease of the joint as an organ. Arthritis Rheum. 2012 Jun;64(6):1697–1707.
  2. Tortorella MD, Burn TC, Pratta MA, et al. Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins. Science. 1999 Jun 4;284(5420):1664–1666.
  3. Pratta MA, Yao W, Decicco C, et al. Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem. 2003 Nov 14;278(46):45539–45545.
  4. Werkmann D, Buyse MA, Dejager L, et al. In vitro characterization of the ADAMTS-5 specific nanobody M6495. Osteoarthritis Cartilage. 2018 Apr;26(Suppl 1):S178.
  5. Van der Aar EM, Desrivot J, Fagard L, et al. ADAMTS-5 inhibitor GLPG1972, a potential new treatment in osteoarthritis, shows favorable safety, pharmacokinetics and pharmacodynamics in healthy subjects. Osteoarthritis Cartilage. 2018 Apr;26(1):S310.
  6. Lindström E, Rizoska B, Tunblad K, et al. The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis. J Transl Med. 2018 Mar 9;16(1):56.
  7. Conaghan PG, Bowes MA, Kingsbury SR, et al. Six months’ treatment with MIV-711, a novel Cathepsin K inhibitor, induces osteoarthritis structure modification: results from a randomized, double-blind, placebo-controlled Phase IIA trial. Osteoarthritis Cartilage. 2018 Apr;26(1):S25–S26.
  8. Jeon OH, Kim C, Laberge RM, et al. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med. 2017 Jun;23(6):775–781.
  9. Yazici Y, McAlindon TE, Gibofsky A, et al. Results from a 52-week, randomized, double-blind, placebo-controlled, phase 2 study of a novel, intra-articular Wnt pathway inhibitor (SM04690) for the treatment of knee osteoarthritis. Osteoarthritis Cartilage. 2018 Apr;26(1):S293–S294.
  10. Timmins KA, Leech RD, Batt ME, et al. Running and knee osteoarthritis: A systematic review and meta-analysis. Am J Sports Med. 2017 May;45(6):1447–1457.
  11. Laslett LL, Dore DA, Quinn SJ, et al. Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: A randomised controlled trial. Ann Rheum Dis. 2012 Aug;71(8):1322–1328.
  12. Sagar DR, Ashraf F, Xu L, et al. Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis. Ann Rheum Dis. 2014 Aug;73(8):1558–1565.
  13. Xing RL, Zhao LR, Wang PM. Bisphosphonates therapy for osteoarthritis: A meta-analysis of randomized controlled trials. Springerplus. 2016 Oct 3;5(1):1704.
  14. Stoppiello LA, Mapp PI, Wilson D, et al. Structural associations of symptomatic knee osteoarthritis. Arthritis Rheumatol. 2014 Nov;66(11):3018–3027.
  15. Lane NE, Schnitzer TJ, Birbara CA, et al. Tanezumab for the treatment of pain from osteoarthritis of the knee. New Engl J Med. 2010 Oct 14;363(16):1521–1531.
  16. Webb MP, Helander EM, Menard BL, et al. Tanezumab: a selective humanized mAb for chronic lower back pain. Ther Clin Risk Manag. 2018 Feb 21;14:361–367.
  17. Schnitzer TJ, Ekman EF, Spierings EL, et al. Efficacy and safety of tanezumab monotherapy or combined with nonsteroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain. Ann Rheum Dis. 2015 Jun;74(6):1202–1211.
  18. Gigout A, Guehring H, Froemel D, et al. Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix. Osteoarthritis Cartilage. 2017 Nov;25(11):1858–1867.
  19. Hochberg M, Guermazi A, Guering H, et al. Efficacy and safety of intra-articular sprifermin in symptomatic radiographic knee osteoarthritis: pre-specified analysis of 3-year data from a 5-year randomised, placebo-controlled, phase II study. Ann Rheum Dis. 2018 Jun;77(Suppl 2):80–81.
  20. Ha CW, Cho JJ, Elmallah RK, et al. A multi-center, single-blind, phase IIa clinical trial to evaluate the efficacy and safety of a cell-mediated gene therapy in degenerative knee arthritis patients. Hum Gene Ther Clin Dev. 2015 Jun;26(2):125–130.
  21. Guermazi A, Kalsi G, Niu J, et al. Structural effects of intra-articular TGFβ-1 in moderate to advanced knee osteoarthritis: MRI-based assessment in a randomized controlled trial. BMC Musculoskelet Disord. 2017;18:461.
  22. Zhang W, Robertson J, Jones AC, et al. The placebo effect and its determinants in osteoarthritis: Meta-analysis of randomised controlled trials. Ann Rheum Dis. 2008 Dec;67(12):1716–1723.

Pages: 1 2 3 4 5 | Single Page

Filed Under: American College of Rheumatology, Conditions, Meeting Reports, Osteoarthritis Tagged With: 2018 ACR/ARHP Annual Meeting, PainIssue: January 2019

You Might Also Like:
  • Secukinumab Inhibits Structural Joint Damage in Active PsA
  • Nonsurgical Therapies for Knee OA Pain: From Medications to Bracing to Exercise, What Works & What Doesn’t
  • Nonsurgical Treatments Can Relieve Pain, Improve Hand Function in Thumb Carpometacarpal Joint Osteoarthritis
  • Osteoarthritis Treatments: Monoclonal Antibody Starts Clinical Trial & Fasinumab Promising for Treating Pain

American College of Rheumatology

Visit the official website for the American College of Rheumatology.

Visit the ACR »

ACR/ARP Annual Meeting

Don’t miss rheumatology’s premier scientific meeting for anyone involved in research or the delivery of rheumatologic care or services.

Visit the ACR Annual Meeting site »

Rheumatology Research Foundation

The Foundation is the largest private funding source for rheumatology research and training in the U.S.

Learn more »

The Rheumatologist newsmagazine reports on issues and trends in the management and treatment of rheumatic diseases. The Rheumatologist reaches 11,500 rheumatologists, internists, orthopedic surgeons, nurse practitioners, physician assistants, nurses, and other healthcare professionals who practice, research, or teach in the field of rheumatology.

About Us / Contact Us / Advertise / Privacy Policy / Terms of Use

  • Connect with us:
  • Facebook
  • Twitter
  • LinkedIn
  • YouTube
  • Feed

Copyright © 2006–2019 American College of Rheumatology. All rights reserved.

ISSN 1931-3268 (print)
ISSN 1931-3209 (online)

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.