The study was not designed to determine whether changes in sensitization are critical for the induction of OA pain or whether changes in sensitization are a consequence of synovitis-induced pain. However, Neogi and colleagues did suggest in their paper that early targeting of inflammation may be successful in preventing pain sensitization and reducing pain severity in patients with knee OA.
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Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
- Walsh DA. Editorial: Synovitis and pain sensitization. Arthritis Rheumatol. 2016 Mar;68(3):561-2. doi: 10.1002/art.39487.
- Neogi T, Guermazi A, Roemer F, et al. Association of joint inflammation with pain sensitization in knee osteoarthritis: The multicenter osteoarthritis study. Arthritis Rheumatol. 2016 Mar;68(3):654–661. doi: 10.1002/art.39488.