Insights into the Metabolic Control of RA T Cells

The researchers then searched for evidence of excess NADPH, which indicated reductive elements were driving these anabolic reactions. They also found ATP^lopyruvate^lo conditions triggered fatty acid biosynthesis, as well as the formation of cytoplasmic lipid droplets. The investigators reversed this metabolic condition by restoring pyruvate production or by inhibiting fatty acid synthesis. These interventions were also able to correct the tissue invasiveness and proarthritogenic behavior of RA T cells in vivo.

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

Reference

Shen Y, Wen Z, Li Y, et al. Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells. Nat Immunol. 2017 Sep;18(9):1025-1034. doi: 10.1038/ni.3808. Epub 2017 Jul 24.

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