The researchers also found a decreased concentration of IL-4 in the supernatant of activated T cells from SLE patients who carry the TT genotype. “Our findings suggest that the TRPC6 genotypes influence the function of circulating immune cells and associate with the risk of developing [neuropsychiatric SLE],” write the authors.
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TRPC6 appears to influence calcium currents, apoptosis rates and cytokine secretion, all in a disease- and genotype-dependent manner. Thus, gene variants associated with the intron polymorphism may at least partially account for the heterogeneity of SLE patients.
Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
- Ramirez GA, Coletto LA, Bozzolo EP, et al. The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function. J Neuroimmunol. 2018 Dec 15;325:43–53.