The transient receptor potential (TRP) ion channel family regulates cross talk between endothelial cells and inflammatory leukocytes. This family of receptors is formed by cation permeable membrane proteins that have a high affinity for Ca++ ions. They may also play an important role in systemic lupus erythematosus (SLE), because overactive Ca++ currents have been described in T and B lymphocytes from SLE patients following membrane receptor activation.
Explore this issueFebruary 2019
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Recent research indicates cells from patients with neuropsychiatric manifestations of SLE who have the transient receptor potential canonical channel 6 (TRPC6) rs7925662 intronic single nucleotide polymorphism (SNP) may be more dependent on TRPC6 for the generation of calcium currents than are individuals without this SNP. These patients are said to have the TT genotype. Giuseppe A. Ramirez, a graduate student at the IRCCS San Raffaele Hospital & Scientific Institute, Italy, and colleagues published their findings in the December 2018 issue of the Journal of Neuroimmunology.1
The researchers began their investigation with 151 SLE patients with who had a median disease duration of 12 years at the time of assessment. Of these, 43.1% had a history of lupus nephritis and 21.9% had a history of neuropsychiatric SLE.
Researchers found the TT genotype associates with a higher incidence of neuropsychiatric SLE. In contrast, no significant difference exists in the cumulative neuropsychiatric SLE incidence between two other TRPC6 genotypes (CC and TC). Moreover, the TT genotype did not associate with lupus nephritis nor did it associate with other non-renal, non-psychiatric SLE phenotypes.