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An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

The Legacy of Amyloid: Infiltration Linked to Dementia, Rheumatic Disease

  |  Issue: October 2017  |  

Simon M. Helfgott, MDSimon M. Helfgott, MD, is associate professor of medicine in the Division of Rheumatology, Immunology and Allergy at Harvard Medical School in Boston.

References

  1. Patel VG, Kalakuntla V, Fortson JK, et al. Stercoral perforation of the sigmoid colon: Report of a rare case and its possible association with nonsteroidal anti-inflammatory drugs. Am Surg. 2002 Jan;68(1):62–64.
  2. Lachmann HJ, Goodman HJB, Gilbertson JA, et al. Natural history and outcome in systemic AA amyloidosis. N Engl J Med. 2007 Jun 7;356(23):2361–2371.
  3. Ramirez-Bermudez, J. Alzheimer’s disease: Critical notes on the history of a medical concept. Arch Med Res. 2012 Nov;43:595–599.
  4. George DR, Whitehouse PJ, D’Alton S, et al. Through the amyloid gateway. Lancet. 2012 Dec 8;380(9858):1986–1987.
  5. Dawkins E, Small DH. Insights into the physiological function of ß amyloid precursor protein: Beyond Alzheimer’s disease. J Neurochem. 2014 Jun;129(5):756–769.
  6. Goedert M, Spillantini MG, Crowther RA. A Brief history of tau. Clin Chem. 2015 Nov;61(11):1417–1418.
  7. Musiek ES, Holtzman DM. Three dimensions of the amyloid hypothesis: Time, space and ‘wingmen.’ Nat Neurosci. 2015 Jun;18(6):800–806.
  8. Drachman DA. The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer’s disease. Alzheimers Dement. 2014 May;10(3):372–380.
  9. Gilman S, Koller M, Black RS, et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology. 2005 May 10;64(9):1553–1562.
  10. Omalu BI, DeKosky ST, Minster RL, et al. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery. 2005 Jul;57(1):128–134; discussion 128–134.
  11. McKee AC, Stern RA, Nowinski CJ, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan;136(Pt 1):43–64.
  12. Roan NR, Sandi-Monroy N, Kohgadai N, et al. Semen amyloids participate in spermatozoa selection and clearance. Elife. 2017 Jun 27;6. pii: e24888.

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