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Links Between Gut Bacteria and Rheumatoid Arthritis

Susan Bernstein  |  Issue: March 2019  |  March 19, 2019


Susan Bernstein is a freelance medical journalist based in Atlanta.

References

  1. Plotz CM, Knowlton AI, Ragan C. The natural history of Cushing’s syndrome. Amer J Med. 1952;13;597–614.
  2. Rosenbaum JT, Silverman GJ. The microbiome and systemic lupus erythematosus. N Engl J Med. 2018 Jun;378:2236–2237.
  3. Scher JU, Abramson SB. The microbiome and rheumatoid arthritis. Nat Rev Rheumatol. 2011 Aug 23;7(10):569–578.
  4. Wu HJ, Ivanov II, Darce J, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via TH helper 17 cells. Immunity. 2010 Jun;32(6):815–827.
  5. Viladomiu M, Kivolowitz C, Abdulhamid A, et al. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote Th17-dependent inflammation. Sci Transl Med. 2017 Feb;9(376):pii: eaaf9655.
  6. Konig MF, Abusleme L, Reinholdt J, et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med. 2016 Dec;8(369).
  7. Wegner N, Wait R, Sroka A, et al. Petidylarginine deiminase from Porphyrmonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum. 2010 Sep;62(9):2662–2672.
  8. Scher JU, Sczesnak A, Longman RS, et al. Expansion of intestinal Prevotella copri correlates to enhanced susceptibility to arthritis. eLife. 2013 Nov 5;2:e01202.
  9. Maeda Y, Kurakawa T, Umemoto E, et al. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol. 2016 Nov;68(11):2646–2661.
  10. Wang QI, Drouin EE, Yao C, et al. Immunogenic HLA-DR-presented self-peptides identified directly from clinical samples of synovial tissue, synovial fluid or peripheral blood in patients with rheumatoid arthritis or Lyme arthritis. J Proteome Res. 2017 Jan;16(1):122–136.
  11. Pianta A, Arvikar S, Strle K, et al. Evidence of the immune relevance of Prevotella copri, a gut microbe, in patients with rheumatoid arthritis. Arthritis Rheumatol. 2017 May;69(5):964–975.
  12. Pianta A, Arvikar S, Strle K, et al. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 1;127(8):2946–2956.
  13. Rose NR. Negative selection, epitope mimicry and autoimmunity. Curr Opin Immunol. 2017 Nov;49:51–55.
  14. Pianta A, Arvikar S, Strle K, et al. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 1;127(8):2946–2956
  15. Rubinstein MR, Wang X, Liu W, et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe. 2013 Aug;14(2):195–206.
  16. Larche M, Wraith DC. Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med. 2005 Apr;11(4 Suppl):S69–S76.

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Filed under:ConditionsMeeting ReportsRheumatoid Arthritis Tagged with:2018 ACR/ARHP Annual MeetingB. fragilisBacteroidesButyricimonasgut microbiomeP. copriperiodontitisPrevotella copri

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