Low Levels of Vitamin D3 May Increase OA Pain

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

References

Lories RJ, Luyten FP. The bone-cartilage unit in osteoarthritis. Nat Rev Rheumatol. 2011 Jan;7(1):43–49. doi: 10.1038/nrrheum.2010.197. Epub 2010 Dec 7.
Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011 Jan;7(1):33–42. doi: 10.1038/nrrheum.2010.196. Epub 2010 Nov 30.
Askari A, Naghizadeh MM, Homayounfar R, et al. Increased serum levels of IL-17A and IL-23 are associated with decreased vitamin D3 and increased pain in osteoarthritis. PLoS One. 2016 Nov 7;11(11):e0164757. doi: 10.1371/journal.pone.0164757. eCollection 2016.

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Background Autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematous, occur when the body attacks its own tissue because it cannot differentiate between self and non-self. This is mainly through deregulation of the immune system. Vitamin D has been known to play a critical role in bone mineralization and bone health. Activated vitamin…

The controversy over vitamin D is hearty enough to confuse even seasoned rheumatologists, says Nathan Wei, MD, The Arthritis Treatment Center, Frederick, Md. “It’s like what you hear with coffee. One week, [a study finds] coffee is … good for you; the next week, there’s a study saying it’s bad for you,” he says. ad…

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