Lupus: Closer to a Cause?

Dr. Choi: We are actively working on trying to utilize these technologies to develop novel drugs. It is a key priority for our labs.

TR: Might drugs that stimulate AHR have implications for other autoimmune diseases besides lupus?

Dr. Rao: Expansion of T_PH cells and activated B cells occurs in many autoantibody-associated autoimmune diseases, including rheumatoid arthritis, Sjögren’s disease and others. It seems likely that strategies that inhibit the T cell-B cell response, including through the activation of AHR, could be beneficial across several of these diseases. 

Conclusion

SLE is complicated for patients and providers alike. Studies like these pave the way for a better understanding, and a better understanding paves the way for better treatment. It’s an exciting time to be a rheumatologist.

Samantha C. Shapiro, MD, is a clinician educator who is passionate about the care and education of rheumatology patients. She writes for both medical and lay audiences and practices telerheumatology.

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