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How to Manage, Treat Anemia of Inflammation in Patients with Rheumatic Disease

Ruth Jessen Hickman, MD  |  Issue: December 2017  |  December 17, 2017

It remains to be seen which of these treatments may prove beneficial for rheumatic patients with anemia of inflammation. As more therapeutic options become available, we will need well-designed clinical trials to determine the optimal management of patients with anemia of inflammation.


Ruth Jessen Hickman, MD, is a graduate of the Indiana University School of Medicine. She is a freelance medical and science writer living in Bloomington, Ind.

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References

  1. Weiss G, Schett G. Anaemia in inflammatory rheumatic diseases. Nat Rev Rheumatol. 2013 Apr;9(4):205–215.
  2. Wilson A, Yu HT, Goodnough LT, Nissenson AR. Prevalence and outcomes of anemia in rheumatoid arthritis: A systematic review of the literature. Am J Med. 2004 Apr 5;116 Suppl 7A:50S–57S.
  3. Furst DE, Chang H, Greenberg JD, et al. Prevalence of low hemoglobin levels and associations with other disease parameters in rheumatoid arthritis patients: Evidence from the CORRONA registry. Clin Exp Rheumatol. 2009 Jul–Aug;27(4):560–566.
  4. Bloxham E, Vagadia V, Scott K, et al. Anaemia in rheumatoid arthritis: Can we afford to ignore it? Postgrad Med J. 2011 Sep;87(1031):596–600.
  5. Nemeth E, Ganz T. Anemia of inflammation. Hematol Oncol Clin North Am. 2014 Aug;28(4):671–681.
  6. Giannouli S, Voulgarelis M, Ziakas PD, et al. Anaemia in systemic lupus erythematosus: From pathophysiology to clinical assessment. Ann Rheum Dis. 2006 Feb;65(2):144–148.
  7. Kostoglou-Athanassiou I, Athanassiou P, Lyraki A, et al. Vitamin D and rheumatoid arthritis. Ther Adv Endocrinol Metab. 2012 Dec;3(6):181–187.
  8. Nairz M, Theurl I, Wolf D, Weiss G. Iron deficiency or anemia of inflammation?: Differential diagnosis and mechanisms of anemia of inflammation. Wien Med Wochenschr. 2016 Oct;166(13):411–423.
  9. Koulaouzidis A, Said E, Cottier R, Saeed AA. Soluble transferrin receptors and iron deficiency, a step beyond ferritin. A systematic review. J Gastrointestin Liver Dis. 2009 Sep;18(3):345–352.
  10. Short MW, Domagalski JE. Iron deficiency anemia: Evaluation and management. Am Fam Physician. 2013 Jan;87(2):98–104.
  11. Nagao T, Hirokawa M. Diagnosis and treatment of macrocytic anemias in adults. J Gen Fam Med. 2017;18:200–204.
  12. Corrado A, Di Bello V, d’Onofrio F, et al. Anti-TNF-α effects on anemia in rheumatoid and psoriatic arthritis. Int J Immunopathol Pharmacol. 2017 Sep;30(3):302–307.
  13. Song SN, Iwahashi M, Tomosugi N, et al. Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients. Arthritis Res Ther. 2013 Oct 2;15(5):R141.

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Filed under:Conditions Tagged with:anemiaCauseClinicalDiagnosisinflammationkidneymacrocytic anemiaManagementoutcomepathophysiologypatient careRheumatic Diseaserheumatologistrheumatologysystemic inflammatory syndromeTestTreatmentvitamin deficiency

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