New Genetic Loci Identified, Epigenome Explored in Juvenile Idiopathic Arthritis

Next steps, he said, should involve identifying all the functional regions within relevant cells—something he said is already underway—as well as identifying specific functional elements of this process, and ultimately building “network models” to understand how transcription is rewired in JIA treatment and testing genetic models in vitro.

Thomas R. Collins is a freelance writer living in South Florida.

References

1. McIntosh L, Marion M, Sudman, et al. Genome-wide association analysis reveals novel juvenile idiopathic arthritis susceptibility loci [abstract 2032]. Arthritis Rheumatol. 2016;68(suppl 10).
2. Jarvis J, Zhu L, Jiang K, et al. A multi-dimensional genomic map for polyarticular juvenile idiopathic arthritis [abstract 2033]. Arthritis Rheumatol. 2016;68(suppl 10).