Patients treated with MIV-711 did have increases in parathyroid hormone levels and decreases in calcium levels, findings that were consistent with the expected mechanism of action of MIV-711.
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The researchers concluded their paper by calling for future studies to determine if the structural benefits they observed will translate into more tangible benefits on OA symptoms.
Lara C. Pullen, PhD, is a medical writer based in the Chicago area.
- Conaghan PG, Bowes MA, Kingsbury SR, et al. Disease-modifying effects of a novel cathepsin K inhibitor in osteoarthritis: A randomized controlled trial. Ann Intern Med. 2020 Jan 21;172(2):86–95.